EDAC: ENCODE Data Analysis Center

描述（由申请人提供）：DNA元件百科全书（ENCODE）项目的目标是使用高通量实验以及计算方法提供人类基因组中所有功能元件的完整清单。该提案旨在创建ENCODE数据分析中心（EDAC或DAC），由一个多学科的领先科学家小组组成，他们将响应ENCODE分析工作组（AWG）的指示，从而以公正的方式整合ENCODE联盟中所有小组生成的数据。这些分析将通过整合不同的数据类型大大增加ENCODE数据的价值。DAC成员在各自的生物信息学、计算机器学习、算法开发、统计理论和基因组数据应用领域都是领导者（Zhiping Weng、Manolis Kellis、Mark Gerstein、Mark Daly、Roderic Guigo、Shirley Liu、Rafael Irizarry和William Noble）。他们在ENCODE和modENCODE项目的背景下提供合作分析方面有着良好的记录，这组研究人员负责ENCODE和modENCODE论文中的大部分分析和大部分图表。拟议的发展援助委员会将追求概括为以下七个目标的目标：与特设工作组合作，定义和优先考虑ENCODE数据的综合分析;目标2.为数据处理、共同分析任务和数据交换提供共享的计算指南和基础设施;目标3.促进和进行元素特异性分析的数据整合;目标4.促进和进行元素间的探索性数据分析;目标5.促进和进行人类、小鼠、苍蝇和蠕虫间的比较分析;目标6.促进与全基因组关联研究社区和疾病数据集的整合;目标7.促进撰写联盟论文并协助评估ENCODE数据。 相关性：DNA元件百科全书（ENCODE）项目是一个协调的努力，应用高通量，具有成本效益的方法，以产生一个全面的人类基因组中的功能元件目录。该提案建立了一个数据分析中心，以支持，促进和加强ENCODE联盟的综合分析，最终目标是促进科学和医学界解释人类基因组，并利用它来了解人类生物学和改善人类健康。

DESCRIPTION (provided by applicant): The objective of the Encyclopedia of DNA Elements (ENCODE) Project is to provide a complete inventory of all functional elements in the human genome using high-throughput experiments as well as computational methods. This proposal aims to create the ENCODE Data Analysis Center (EDAC, or the DAC), consisting of a multi-disciplinary group of leading scientists who will respond to directions from the Analysis Working Group (AWG) of ENCODE and thus integrate data generated by all groups in the ENCODE Consortium in an unbiased manner. These analyses will substantially augment the value of the ENCODE data by integrating diverse data types. The DAC members are leaders in their respective fields of bioinformatics, computational machine learning, algorithm development, and statistical theory and application to genomic data (Zhiping Weng, Manolis Kellis, Mark Gerstein, Mark Daly, Roderic Guigo, Shirley Liu, Rafael Irizarry, and William Noble). They have a strong track record of delivering collaborative analysis in the context of the ENCODE and modENCODE Projects, in which this group of researchers was responsible for the much of the analyses and the majority of the figures and tables in the ENCODE and modENCODE papers. The proposed DAC will pursue goals summarized as the following seven aims: Aim 1. To work with the AWG to define and prioritize integrative analyses of ENCODE data; Aim 2.To provide shared computational guidelines and infrastructure for data processing, common analysis tasks, and data exchange; Aim 3. To facilitate and carry out data integration for element-specific analyses; Aim 4.To facilitate and carry out exploratory data analyses across elements; Aim 5.To facilitate and carry out comparative analyses across human, mouse, fly, and worm; Aim 6.To facilitate integration with the genome-wide association studies community and disease datasets; and Aim 7.To facilitate writing Consortium papers and assist evaluating ENCODE data. RELEVANCE: The Encyclopedia of DNA Elements (ENCODE) Project is a coordinated effort to apply high-throughput, cost-efficient approaches to generate a comprehensive catalog of functional elements in the human genome. This proposal establishes a data analysis center to support, facilitate, and enhance integrative analyses of the ENCODE Consortium, with the ultimate goal of facilitating the scientific and medical communities in interpreting this human genome and using it to understand human biology and improve human health.