Genetic Ancestry Inference: Developing Best-Practice Guidelines

遗传祖先推断：制定最佳实践指南

• 批准号: 8656831
• 负责人: Michael Dougherty
• 金额: $ 3.08万
• 依托单位: AMERICAN SOCIETY OF HUMAN GENETICS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-25 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656831
• 关键词: Academia; Accountability; Address; Advisory Committees; Advocacy; American; Anthropology; Behavioral; Benchmarking; Chicago; Communication Research; Communities; Databases; Education; Financial Support; Genetic; Genomics; Guidelines; Health Personnel; Human Genetics; Individual; Industry; Interest Group; Journals; Legal; Methods; Participant; Population; Positioning Attribute; Practice Guidelines; Publishing; Recommendation; Research; Research Personnel; Research Subjects; Safety; Scientist; Societies; Solutions; Test Result; Testing; Travel; expectation; genetic epidemiology; improved; interdisciplinary collaboration; meetings; social

DESCRIPTION (provided by applicant): The American Society of Human Genetics (ASHG) requests financial support to partially defray speaker and participant travel expenses for an "Ancestry Inference Roundtable" to be held in May, 2012, in Chicago, IL. This meeting will build on an earlier ASHG position statement (ASHG, 2008) and the recommendations of an ASHG ancestry task force, which were published in the American Journal of Human Genetics (Royal et al., 2010). The purpose of the meeting will be to facilitate further discussion with a broader community of ancestry researchers, direct-to-consumer ancestry testing companies, and other stakeholders and to develop best practices and guidelines regarding genetic ancestry inference in academia and industry. The specific aims of the roundtable are to develop: 1. Best practices for inferring genetic and genomic ancestry; 2. Guidelines for the application and presentation of genetic ancestry inference results in different settings in industry and academia - personal ancestry testing, genetic epidemiology, genetic anthropology, etc.; 3. Strategies for encouraging use of best practices and guidelines; 4. Mechanisms for determining and addressing the potential impact of genetic ancestry inference on individuals and communities; and 5. Recommendations for education and engagement about genetic ancestry information. A Planning Committee of experts representing a diverse and essential constituency, chaired by Dr. Charmaine Royal and Dr. Michael Bamshad, has been assembled and will provide intellectual direction for the project. The roundtable discussions will be organized and hosted by ASHG, which is also providing financial and logistical support.

描述（由申请人提供）：美国人类遗传学会（ASHG）要求财政支持，以部分支付将于2012年5月在伊利诺伊州芝加哥举行的“祖先推论圆桌会议”的演讲者和参与者的旅费。本次会议将建立在ASHG早期的立场声明（ASHG, 2008）和ASHG祖先工作组的建议基础上，这些建议发表在美国人类遗传学杂志上（Royal et al., 2010）。会议的目的是促进与更广泛的祖先研究人员、直接面向消费者的祖先检测公司和其他利益相关者的进一步讨论，并制定学术界和工业界关于遗传祖先推断的最佳实践和指导方针。圆桌会议的具体目标是：推断遗传和基因组祖先的最佳做法；2. 遗传祖先推断结果在工业和学术界不同环境中的应用和呈现指南-个人祖先测试，遗传流行病学，遗传人类学等；3. 鼓励使用最佳做法和准则的战略；4. 确定和处理遗传祖先推断对个人和社区的潜在影响的机制；和5。关于遗传祖先信息的教育和参与的建议。由Charmaine Royal博士和Michael Bamshad博士担任主席的代表不同和重要群体的专家组成的规划委员会已经成立，并将为该项目提供思想指导。圆桌讨论会将由ASHG组织和主持，ASHG也将提供资金和后勤支持。

项目成果

Guidelines for genetic ancestry inference created through roundtable discussions.

• DOI: 10.1016/j.xhgg.2023.100178
• 发表时间: 2023-04-13
• 期刊: HUMAN GENETICS AND GENOMICS ADVANCES
• 作者: Wagner, Jennifer K.;Yu, Joon-Ho;Fullwiley, Duana;Moore, CeCe;Wilson, James F.;Bamshad, Michael J.;Royal, Charmaine D.
• 通讯作者: Royal, Charmaine D.