HIV 抗逆转录病毒治疗对人口健康影响的因果途径-猫眼课题宝

HIV 抗逆转录病毒治疗对人口健康影响的因果途径

批准号：

9561910

负责人：

Till Barnighausen

金额：

$45.1万

依托单位：

KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV

依托单位国家：

美国

项目类别：

财政年份：

2015

资助国家：

美国

项目状态：

已结题

起止时间：

2015-09-11 至 2021-12-31

来源：

https://reporter.nih.gov/project-details/9561910

关键词：

Adult Africa Africa South of the Sahara Age Area Attention Attitude Autopsy Behavior Therapy Behavioral Biological Biological Markers Blood Caring Cause of Death Cessation of life Clinic Clinical Collection Communities Data Demographic Analyses Disease Ensure Epidemiology Exposure to Financial compensation Funding Future Goals HIV HIV Infections HIV antiretroviral HIV risk Health Health Services Accessibility Household Human immunodeficiency virus test Improve Access Incidence Individual Infrastructure Intervention Knowledge Life Life Expectancy Link Measures Mentors National Institute of Child Health and Human Development Paper Pathway interactions Patients Perception Persons Population Population Study Postdoctoral Fellow Prevention Prevention strategy Preventive Preventive Intervention Public Health Schools Public Sector Publishing Records Recovery Research Residencies Risk Risk Reduction Role Rural Rural Community Savings Schools Science Sex Behavior Shapes South Africa South African Spottings Testing Treatment Efficacy Treatment Failure United States National Institutes of Health Universities Viral Load result Work antiretroviral therapy behavioral response cohort design evidence base follow-up high risk improved outcome infection risk member mortality national surveillance next generation optimism population based population health programs public health relevance recruit rural South Africa scale up socioeconomics surveillance data therapy adherence

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中文摘要

翻译

描述（由申请人提供）：抗逆转录病毒治疗的扩大已经改变了南非艾滋病毒流行人群的健康状况，预期寿命获得了前所未有的提高（Bor等人，2013），艾滋病毒发病率显著降低（Tanser等人，2013）。为了实现扩大抗逆转录病毒疗法的全部潜在效益，需要进一步的证据来说明抗逆转录病毒疗法覆盖率降低发病率的途径（行为与生物），以及为什么在有挽救生命的抗逆转录病毒疗法的情况下，仍有这么多艾滋病毒感染者死亡。我们将通过分析来自农村夸祖鲁-纳塔尔的人口和健康监测数据来建立这一证据基础。这项研究将为干预措施提供信息，以最大限度地发挥南非ART计划的影响。

英文摘要

DESCRIPTION (provided by applicant): The scale-up of antiretroviral therapy has transformed the health of HIV-endemic populations in South Africa, with unprecedented gains in life expectancy (Bor et al. 2013) and significant reductions in HIV incidence (Tanser et al. 2013). To achieve the full potential benefits of ART scale-up, further evidence is needed on the pathways (behavioral vs. biological) through which ART coverage reduces incidence, and the reasons why so many people with HIV continue to die when life-saving ART is available. We will establish this evidence base through analysis of demographic and health surveillance data from rural KwaZulu-Natal. This research will inform interventions to maximize the impact of South Africa's ART program.

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