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Causal Pathways to population health impact of HIV antiretroviral treatment

Causal Pathways to population health impact of HIV antiretroviral treatment
HIV 抗逆转录病毒治疗对人口健康影响的因果途径
批准号：
9561910
负责人：
Till Barnighausen
金额：
$45.1万
依托单位：
KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-09-11 至 2021-12-31
来源：
https://reporter.nih.gov/project-details/9561910
关键词：
AdultAfricaAfrica South of the SaharaAgeAreaAttentionAttitudeAutopsyBehavior TherapyBehavioralBiologicalBiological MarkersBloodCaringCause of DeathCessation of lifeClinicClinicalCollectionCommunitiesDataDemographic AnalysesDiseaseEnsureEpidemiologyExposure toFinancial compensationFundingFutureGoalsHIVHIV InfectionsHIV antiretroviralHIV riskHealthHealth Services AccessibilityHouseholdHuman immunodeficiency virus testImprove AccessIncidenceIndividualInfrastructureInterventionKnowledgeLifeLife ExpectancyLinkMeasuresMentorsNational Institute of Child Health and Human DevelopmentPaperPathway interactionsPatientsPerceptionPersonsPopulationPopulation StudyPostdoctoral FellowPreventionPrevention strategyPreventivePreventive InterventionPublic Health SchoolsPublic SectorPublishingRecordsRecoveryResearchResidenciesRiskRisk ReductionRoleRuralRural CommunitySavingsSchoolsScienceSex BehaviorShapesSouth AfricaSouth AfricanSpottingsTestingTreatment EfficacyTreatment FailureUnited States National Institutes of HealthUniversitiesViral Load resultWorkantiretroviral therapybehavioral responsecohortdesignevidence basefollow-uphigh riskimproved outcomeinfection riskmembermortalitynational surveillancenext generationoptimismpopulation basedpopulation healthprogramspublic health relevancerecruitrural South Africascale upsocioeconomicssurveillance datatherapy adherence

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英文摘要
 DESCRIPTION (provided by applicant): The scale-up of antiretroviral therapy has transformed the health of HIV-endemic populations in South Africa, with unprecedented gains in life expectancy (Bor et al. 2013) and significant reductions in HIV incidence (Tanser et al. 2013). To achieve the full potential benefits of ART scale-up, further evidence is needed on the pathways (behavioral vs. biological) through which ART coverage reduces incidence, and the reasons why so many people with HIV continue to die when life-saving ART is available. We will establish this evidence base through analysis of demographic and health surveillance data from rural KwaZulu-Natal. This research will inform interventions to maximize the impact of South Africa's ART program.
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