AMINISTRATIVE CORE

行政核心

• 批准号: 8514332
• 负责人: MITCHEL S. BERGER
• 金额: $ 16.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514332
• 关键词: American; Animals; Antibodies; Archives; Biological Assay; Biological Preservation; Biometry; Brain Neoplasms; Cell Survival; Cells; Clinical; Clinical Trials; Collection; DNA; Data; Data Quality; Databases; Development; Drug or chemical Tissue Distribution; Ensure; Equipment and supply inventories; Fluorescent in Situ Hybridization; Funding; Genes; Genomics; Glioma; Goals; Grant; Guidelines; Harvest; Histopathology; Human; Image Guided Biopsy; Immunohistochemistry; Institution; Instruction; Link; Mission; Modality; Molecular; Online Systems; Operating Rooms; Pathologist; Pathology; Patients; Preparation; Principal Investigator; Procedures; Process; Proteins; Quality Control; RNA; Research; Research Project Grants; Resources; Sampling; Specimen Handling; Spectrum Analysis; System; Techniques; Technology; Tissue Microarray; Tissues; Translational Research; Tumor Tissue; Xenograft procedure; college; computerized; data sharing; meetings; neuro-oncology; novel; success; tissue/cell culture; usability; vaccine development

The Brain Tumor SPORE Biospecimen/Pathology Core provides staff and technology dedicated to enhancing brain tumor biospecimen integrity and usability through use of optimized collection procedures; multi-modality preservation, processing, and analysis; histopathologic-molecular characterization; and computerized inventory and web-based request and tracking systems. All aspects of sample identification, processing and storage are performed with strict compliance to the College of American Pathologists (CAP) guidelines. In order to maximize sharing and integration of SPORE projects, the Tissue Core collects and makes available data derived from all distributed brain tumor biospecimens. Specific Aims of the SPORE Biospecimen/Pathology Core: A. To acquire brain tumor patient biospecimens from the operating room and SPORE Animal Core with optimized handling to maximize cell viability and/or minimize the warm-ischemic interval so as to meet the tissue accrual requirements for the Brain Tumor SPORE projects and clinical trials. This aim is essential for all Projects. B. To perform quality control assays on archived brain tumor biospecimens collected from the operating room and SPORE Animal Core, to ensure availability of adequate numbers of consistently handled specimens that will yield high quality data for SPORE projects and clinical trials. C. To provide routine and advanced tissue handling/processing and analytical techniques, including immunohistochemistry, fluorescence in situ hybridization (FISH), tissue microarray construction, DNA/RNA extraction, protein isolation, and preparation of viable cells thatwill advance project hypothesis development and goal attainment. D. To maintain a database containing demographic data, results from molecular analyses, and brain tumor patient biospecimen distributions (internal and external) that will be linked to relational clinical databases maintained by the Biostatistics and Clinical Core. RELEVANCE (See instructions): The Brain Tumor SPORE Biospecimen/Pathology Core is dedicated to the optimization of human and animal brain tumor biospecimen collection, storage, use, distribution, and sharing of data from studies using this precious resource. The Core is essential for the high impact translational goals of each Brain Tumor SPORE Projects.

脑肿瘤孢子生物标本/病理学核心提供专门的工作人员和技术， 通过使用优化的收集程序，提高脑肿瘤生物标本的完整性和可用性; 多模态保存、处理和分析;组织病理学-分子表征;以及 计算机化库存和基于网络的请求和跟踪系统。样品鉴定的所有方面， 严格按照美国病理学家学会（CAP）的要求进行处理和储存 指南为了最大限度地共享和整合SPORE项目，Tissue Core收集并 提供来自所有分发的脑肿瘤生物标本的数据。 SPORE生物标本/病理学核心的具体目标： A.从手术室和SPORE Animal Core采集脑肿瘤患者生物标本， 优化处理以使细胞活力最大化和/或使热缺血间隔最小化，从而满足 脑肿瘤孢子项目和临床试验的组织累积要求。这一目标对于以下方面至关重要： 所有项目。 B。对从手术室采集的存档脑肿瘤生物标本进行质量控制检测， 房间和孢子动物核心，以确保提供足够数量的一致处理的 这些样本将为SPORE项目和临床试验提供高质量的数据。 C.提供常规和先进的组织处理/加工和分析技术，包括 免疫组织化学、荧光原位杂交、组织芯片构建、DNA/RNA 提取、蛋白质分离和制备活细胞，这将促进项目假设的发展 和目标实现。 D.维护包含人口统计学数据、分子分析结果和脑肿瘤的数据库 患者生物样本分布（内部和外部），将链接到相关临床数据库 由生物统计学和临床核心维护。 相关性（参见说明）： 脑肿瘤孢子生物标本/病理学核心致力于优化人类和动物 脑肿瘤生物标本的收集、储存、使用、分发和共享来自使用该研究的数据。 宝贵的资源。核心对于每个脑肿瘤孢子的高影响力转化目标至关重要 项目