寻求和治疗艾滋病毒的最佳结果和预防-猫眼课题宝

寻求和治疗艾滋病毒的最佳结果和预防

批准号：

8582709

负责人：

Julio Sergio Gonzalez Montaner

金额：

$10.1万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

依托单位国家：

美国

项目类别：

财政年份：

2008

资助国家：

美国

项目状态：

已结题

起止时间：

2008-09-05 至 2013-07-31

来源：

https://reporter.nih.gov/project-details/8582709

关键词：

AIDS/HIV problem Acquired Immunodeficiency Syndrome Adherence Adverse event Alcohol or Other Drugs use Antiretroviral resistance British Columbia CD4 Lymphocyte Count Canada Caring Characteristics Charge Child Chronic Clinical Collaborations Combined Modality Therapy Comorbidity Couples Data Databases Diagnostic Dose Drug usage Effectiveness Ensure Epidemic Generations HIV HIV Infections HIV-1 Health Healthcare Hepatitis B Virus Hepatitis C virus Heterosexuals Highly Active Antiretroviral Therapy Hospitalization Hospitals Immune Incentives Incidence Individual Infection International Intervention Laboratories Lead Measures Medical Mental Depression Mental disorders Monitor Morbidity - disease rate Mothers Names National Institute of Drug Abuse Outcome Participant Patients Pattern Pharmaceutical Preparations Phylogenetic Analysis Plasma Play Population Positioning Attribute Prevalence Prevention Preventive Principal Investigator Publications RNA Randomized Clinical Trials Recovery Recruitment Activity Regimen Reporting Research Resistance Resources Risk Behaviors Role Safety San Francisco Seminal fluid Services Severities Social Network Source Substance abuse problem System Taiwan Techniques Testing Therapeutic Toxic effect Trees Vaccines Vagina Vertical Disease Transmission Viral Viral Load result Vital Statistics base case finding cohort comparative contingency management essays experience genome sequencing high risk innovation insight interest mortality neglect novel novel strategies performance tests prevent prognostic programs social therapy adherence therapy outcome transmission process uptake

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DESCRIPTION (provided by applicant): The HIV/AIDS epidemic continues to grow rapidly, throughout the world. This is likely to remain so because i) HIV cannot be cured, ii) prevention is neglected and iii) a preventive vaccine remains elusive. In contrast, on the therapeutics front there has been tremendous progress. Since 1996, highly active antiretroviral therapy (HAART) has transformed AIDS into a chronic manageable illness. HAART stops HIV replication, therefore turning plasma viral levels to undetectable levels (<50 c/mL). This leads to a sustained immune recovery and near normal health. HAART has also been shown to decrease HIV levels in semen and vaginal secretions. As a result there has been growing interest regarding the possible role of HAART in directly preventing HIV transmission by decreasing infectiveness of those on treatment. Supportive evidence for "HAART as Prevention" first emerged in vertical transmission studies where, ultimately, HIV transmission from the infected mother to her child has become exceedingly rare if HAART is in place. A possible effect of HAART on decreasing HIV transmission has been incidentally observed in HIV serodiscordant heterosexual couples and separately in population-level studies from Taiwan, San Francisco and in our own study in British Columbia, Canada. We therefore propose to prospectively test the "HAART as Prevention" hypothesis, with a special focus on IDU. Specifically we propose to test that: 1) expanded HAART coverage among IDU will lead to a decrease in the number of new HIV infections within the population, including but not restricted to IDU; and 2) expanded HAART coverage among IDU, will lead to a decrease in adverse HIV/AIDS health outcomes among IDU. This proposal, named "Seek and Treat for Optimal Outcomes and Prevention in HIV & AIDS in IDU", represents both a groundbreaking and innovative research hypothesis with important consequences for the control of the global HIV epidemic.

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