Eye and Vision Genomics Training Program

根据RFA-EY-10-001，我们正在提交一份修订后的申请，申请国家眼科研究所（NEI） Ruth L. Kirschstein国家研究服务奖（NRSA）机构研究补助金（T32），以开发一个新的统计遗传学和基因组信息学培训项目，重点研究眼病和视力障碍。这项新的培训计划的使命是培养博士预科生和博士后研究员，使他们能够熟练地将统计遗传学和生物信息学工具应用于眼部疾病和视力障碍的研究。该提案汇集了来自约翰霍普金斯大学彭博公共卫生学院（SPH）和医学院（SOM）不同部门的统计遗传学、遗传流行病学、生物统计学、眼科学、分子生物学和生物信息学方面的专业人员。我们将招收流行病学系（主要是遗传流行病学专业的学生）和生物统计系的博士预科生，以及对基因组研究定量方面感兴趣的合格博士后研究员，并将让所有学员参与SOM正在进行的与眼基因组学相关的研究项目（包括威尔默眼科研究所和遗传医学研究所）。本项目资助的3名博士预科生和1名博士后将在统计遗传学、遗传流行病学、生物统计学和基因组信息学等方面进行重点培训。除了项目主任和联合项目主任外，11个核心学院以及视觉研究、遗传学和信息学的附属学院将为该项目做出贡献，他们代表了统计遗传学、遗传流行病学、计算统计学、生物统计学、分子遗传学、临床遗传学和眼科学等领域。本修订后的新培训计划申请旨在为受训者提供必要的多学科背景，以便在以眼部疾病和视觉障碍为重点的基因组研究中进行定量研究。

DESCRIPTION (provided by applicant): In response to RFA-EY-10-001, we are submitting a revised application for a National Eye Institute (NEI) Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Grant (T32) to develop a new training program in statistical genetics and genome informatics focused on eye diseases and vision disorders. The mission of this new training program will be to train pre-doctoral students and post-doctoral fellows to become research leaders adept in applying the tools of statistical genetics and bioinformatics to ocular diseases and vision disorders. This proposal brings together faculty with expertise in statistical genetics, genetic epidemiology, biostatistics, ophthalmology, molecular biology and bioinformatics from different departments in the Johns Hopkins University Bloomberg School of Public Health (SPH) and the School of Medicine (SOM). We will recruit pre-doctoral students from the Dept. of Epidemiology (primarily students in the Genetic Epidemiology Area of Concentration) and the Dept. of Biostatistics, as well as eligible post-doctoral fellows interested quantitative aspects of genomic research and will involve all trainees in ongoing research projects related to ocular genomics in the SOM (including the Wilmer Eye Institute and the Institute of Genetic Medicine). The 3 pre-doctoral and 1 post-doctoral trainees supported by this program will pursue a focused training program consisting of: didactic courses in statistical genetics, genetic epidemiology, biostatistics and genomic informatics. In addition t the Program Director and co-Program Director, 11 Core Faculty along with Affiliate Faculty in vision research and genetics and informatics will contribute to this program, representing the fields of statistical genetics, genetic epidemiology, computational statistics, biostatistics, molecular genetics, clinical genetics and ophthalmology. This revised application for new training program is designed to provide trainees with the multidisciplinary background essential to conduct quantitative studies in genomic research focused on ocular diseases and visual disorders.