Cancer Biology

该计划在癌症生物学的重点是调查机制和信号通路 参与细胞的恶性转化。目标是促进对 癌症发病机制，并将基础科学发现转化为临床竞技场，以改善 癌症患者的结局。该计划包括三个主要主题组：1） 肿瘤发生的机制和途径; 2）细胞周期、细胞骨架和基因组稳定性;以及3） 上皮性肿瘤（包括皮肤癌、前列腺癌和肺癌亚组）。调查的重点是 癌基因和抑癌基因的机制研究，细胞分裂的控制，基因组 稳定性和DNA损伤检查点，以及血液学中疾病特异性兴趣 恶性肿瘤、皮肤癌、前列腺癌和肺癌。40名调查人员代表两个不同的学校（ 医学院和人文与科学学院），16个部门，和五个部门内 医学系。40名研究人员的研究活动得到了73名同行评审人员的支持， 赞助商发起的赠款（R 01和其他），和五个T32培训奖。NCI共计 其他NIH支持为720万美元，非NIH支持为320万美元。以来 2005年，项目研究人员在同行评审中发表了400多篇与癌症生物学相关的手稿。 期刊癌症中心将继续在协助翻译 将该项目的基础科学发现转化为新的临床诊断方法， 治疗癌症患者。

The Program in Cancer Biology is focused on investigations into mechanisms and signaling pathways involved in the malignant transformation of cells. The goals are to advance basic understanding of cancer pathogenesis and to translate basic science discoveries into the clinical arena to improve the outcome of patients with cancer. The Program encompasses three major thematic groups: 1) Mechanisms and Pathways of Oncogenesis; 2) Cell Cycle, Cytoskeleton and Genomic Stability; and 3) Epithelial Neoplasia (including skin, prostate and lung cancer subgroups). Investigations are focused on mechanistic studies of oncogenes and tumor suppressor genes, the control of cell division, genomic stability and DNA damage checkpoints, as well as disease-specific interests in hematologic malignancies, skin, prostate and lung cancers. The 40 investigators represent two different schools (the School of Medicine and the School of Humanities & Sciences), 16 Departments, and five Divisions within the Department of Medicine. The research activities of the 40 investigators are supported by 73 peer-reviewed, investigator-initiated grants (R01s and others), and five T32 training awards. Total NCI support is $4.3 million, other NIH support is $7.2 million, and non-NIH support is $3.2 million. Since 2005, program investigators have published over 400 manuscripts relevant to cancer biology in peer-reviewed journals. The Cancer Center will continue to be invaluable in assisting with the translation of the basic science findings from this Program into new clinical approaches for the diagnosis and treatment of patients with cancer.