Project 2: Analyzing Patterns In Epidemiologic and Toxicologic Data
项目 2:分析流行病学和毒理学数据的模式
基本信息
- 批准号:8723399
- 负责人:
- 金额:$ 0.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AcademiaAccountingAddressAreaAttention deficit hyperactivity disorderBehaviorBirthCase-Control StudiesChemicalsChildCodeCohort StudiesCollaborationsCommunity PracticeComputer softwareCongenital AbnormalityDataData SetDevelopmentDiseaseEnvironmental EpidemiologyEnvironmental HazardsEpidemiologic StudiesEpidemiologistEpidemiologyEvaluationExposure toGovernmentHazardous SubstancesHazardous WasteHealthHot SpotHumanIndividualInstructionInvestigationKnowledgeLifeMapsMassachusettsMetalsMethodsModelingMothersOutcomePatternPerformancePolychlorinated BiphenylsPopulationPopulation DensityPsychological TechniquesResearchRhode IslandRiskRisk AssessmentRisk FactorsRunningSamplingSignal Recognition ParticleSoftware ToolsSource CodeStatistical ModelsTetrachloroethyleneTimeToxic effectToxicologyTranslational ResearchTrihalomethanesWeightWorkWritingbasebiological systemscohortcommunity organizationsepidemiologic datainterestmathematical modelnovelnovel strategiesopen sourcereceptorreproductivesuperfund chemicalsuperfund sitetooltrenduser friendly software
项目摘要
Project 2 evaluates advanced methods for analyzing patterns in epidemiologic and toxicologic data involving
combinations of space and time or combinations of chemicals (mixtures). Two SRP mandates are
addressed: (1) advanced technicues to detect associations between human health effects and
environmental hazards; (2) methods to assess the risks to human health presented by hazardous
substances. There are four related research aims and one research translation aim. Aim 1 is a rigorous
evaluation of the use of tensor product smooths in generalized additive models (GAMs) to analyze spacetime
interactions in epidemiological data. GAMs predict local disease odds over time while adjusting for
known risk factors in the population. Aim 2 will apply GAM methods to investigate patterns in space and time
for two populations: birth defects in parts of Massachusetts and Rhode Island (formal collaboration with SRP
Project 1), and Attention Deficit Hyperactivity Disorder (ADHD)-related behaviors in children born while their
mothers were living near the New Bedford Harbor Superfund Site. Aim 3 extends the application of our
spatial methods to the analysis of chemical mixtures (formal collaboration with SRP Projects 4 and 6). In Aim
4, we assess combinations of exposures in epidemiology, adapting methods from toxicology. Aim 5 will
make the methods developed in our project freely available via open source software, in collaboration with
the Research Translation Core. The novel methods from this project should be of interest to academia,
government and community organizations.
项目2评估流行病学和毒理学数据分析模式的先进方法,
空间和时间的组合或化学品的组合(混合物)。战略调整方案的两项任务是:
处理:(1)检测人类健康影响与
环境危害;(2)评估有害物质对人类健康风险的方法
物质.有四个相关的研究目标和一个研究翻译目标。目标1是一个严格的
在分析时空的广义加性模型中使用张量积平滑的评价
流行病学数据的相互作用。GAM预测局部疾病的几率随着时间的推移,
人群中已知的危险因素。目标2将应用GAM方法研究空间和时间模式
针对两个人群:马萨诸塞州和罗得岛部分地区的出生缺陷(与SRP正式合作
项目1),以及注意缺陷多动障碍(ADHD)相关行为的儿童出生时,
母亲们住在新贝德福德海港超级基金附近。Aim 3扩展了我们的
化学混合物分析的空间方法(与SRP项目4和6正式合作)。在Aim中
4.我们评估流行病学中的暴露组合,采用毒理学方法。目标5将
通过开源软件免费提供我们项目中开发的方法,与
研究翻译核心这个项目的新方法应该会引起学术界的兴趣,
政府和社区组织。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Veronica M Vieira其他文献
Veronica M Vieira的其他文献
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{{ truncateString('Veronica M Vieira', 18)}}的其他基金
Spatial and Temporal Modeling of PM2.5 and Infant Morbidity
PM2.5 和婴儿发病率的时空建模
- 批准号:
8306911 - 财政年份:2011
- 资助金额:
$ 0.78万 - 项目类别:
Spatial and Temporal Modeling of PM2.5 and Infant Morbidity
PM2.5 和婴儿发病率的时空建模
- 批准号:
8487403 - 财政年份:2011
- 资助金额:
$ 0.78万 - 项目类别:
Spatial and Temporal Modeling of PM2.5 and Infant Morbidity
PM2.5 和婴儿发病率的时空建模
- 批准号:
8668057 - 财政年份:2011
- 资助金额:
$ 0.78万 - 项目类别:
Spatial and Temporal Modeling of PM2.5 and Infant Morbidity
PM2.5 和婴儿发病率的时空建模
- 批准号:
8193368 - 财政年份:2011
- 资助金额:
$ 0.78万 - 项目类别:
A Temporal-Spatial Analysis of Breast Cancer in Upper C*
上 C* 乳腺癌的时空分析
- 批准号:
7058552 - 财政年份:2005
- 资助金额:
$ 0.78万 - 项目类别:
A Temporal-Spatial Analysis of Breast Cancer in Upper C*
上 C* 乳腺癌的时空分析
- 批准号:
7127615 - 财政年份:2005
- 资助金额:
$ 0.78万 - 项目类别:
Project 2: Analyzing Patterns In Epidemiologic and Toxicologic Data
项目 2:分析流行病学和毒理学数据的模式
- 批准号:
8828190 - 财政年份:
- 资助金额:
$ 0.78万 - 项目类别:
Project 2: Analyzing Patterns In Epidemiologic and Toxicologic Data
项目 2:分析流行病学和毒理学数据的模式
- 批准号:
8289721 - 财政年份:
- 资助金额:
$ 0.78万 - 项目类别:
Project 2: Analyzing Patterns In Epidemiologic and Toxicologic Data
项目 2:分析流行病学和毒理学数据的模式
- 批准号:
8548347 - 财政年份:
- 资助金额:
$ 0.78万 - 项目类别:
Project 2: Analyzing Patterns In Epidemiologic and Toxicologic Data
项目 2:分析流行病学和毒理学数据的模式
- 批准号:
9043073 - 财政年份:
- 资助金额:
$ 0.78万 - 项目类别:
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