Efficacy of Eldecalcitol (ED-71) in Colorectal Cancer
Efficacy of Eldecalcitol (ED-71) in Colorectal Cancer
批准号:
8739520
负责人:
Michael Pawlita
金额:
$30.37万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-18 至 2014-09-17
关键词:
AgeAnimalsApoptosisBiological MarkersBlood Chemical AnalysisBlood specimenBody WeightBreedingCarbon DioxideCell ProliferationChemopreventive AgentCholecalciferolColon CarcinomaColonic NeoplasmsColonic PolypsColorectal CancerContractorContractsControl GroupsDietDoseEffectivenessEuthanasiaFemaleFrequenciesGene Expression ProfileGeneticImmunohistochemistryIncidenceIntestinal NeoplasmsIntestinesLiverMediatingMessenger RNAMethodsMicroRNAsMolecular TargetMusOrganPre-Clinical ModelReverse Transcriptase Polymerase Chain ReactionSerumSerum Calcium LevelSignal TransductionSignaling MoleculeSmall Intestinal NeoplasmSmall Intestinal PolypStagingSymptomsTestingTissuesToxic effectTumor SuppressionTumor TissueWestern Blottingbasecancer preventioncolorectal cancer preventionfeedingin vivomalemouse modelpreventresearch studyresponsetumor
中文摘要
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英文摘要
The overall objective is to develop Eldecalcitol (ED-71) for colorectal cancer prevention in a preclinical model. Specifically, the Contractor shall obtain required quantities of ED-71, establish the optimal dose and/or non-calcemic dose, perform in depth assessment of ED-7-mediated colon cancer prevention in APC-min mice, in addition to, identifying ED-71 specific molecular target(s) in preventing tumor frequency, incidence, multiplicity, etc. in APC-min mice.
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会议论文
Patterns of Care/Quality of Care Study - Diagnosis Year 2012; HHSN261201300010I T
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批准号:8752581
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项目类别:
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资助金额:$2.23万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Surveillance, Epidemiology, and End Results (SEER) Program
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批准号:8743667
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项目类别:
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资助金额:$255.05万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
MUC1 Vaccine in Patients with Newly Diagnosed Advanced Adenomas
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批准号:8762914
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项目类别:
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资助金额:$93.95万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Core Infrastructure Support
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批准号:8762909
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项目类别:
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资助金额:$61.21万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Surveillance, Epidemiology, and End Results (SEER) Program
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批准号:8743669
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项目类别:
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资助金额:$301.5万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Preclinical Pharmacology and Toxicology Studies
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批准号:8739512
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项目类别:
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资助金额:$16.58万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Chemoprevention of Prostate Cancer via Estrogen Receptor B Agonists
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批准号:8739519
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项目类别:
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资助金额:$68.63万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Surveillance, Epidemiology, and End Results (SEER) Program
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批准号:8743670
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项目类别:
-
资助金额:$239.52万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Effects Of Chemopreventive Agents On Biomarkers Related To Lung Tumorigenesis: Al
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批准号:8760456
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项目类别:
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资助金额:$61.5万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Program Evaluaton, Planning and Coordination Services
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批准号:8765321
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项目类别:
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资助金额:$0.46万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Patterns of Care/Quality of Care Study - Diagnosis Year 2012; HHSN261201300004I T
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批准号:8752567
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项目类别:
-
资助金额:$12.89万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) PROGRAM
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批准号:8743686
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项目类别:
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资助金额:$198.3万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Patterns of Care/Quality of Care - Diagnosis Year 2012
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批准号:8752965
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项目类别:
-
资助金额:$14.97万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Surveillance, Epidemiology, and End Results (SEER) Program
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批准号:8725353
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项目类别:
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资助金额:$102.81万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Evaluation of iNOS Antagonists in the Prevention of Oral Cancer - HHSN261201200
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批准号:8760480
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项目类别:
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资助金额:$62.13万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Patterns of Care/Quality of Care Study - Diagnosis Year 2012; HHSN261201300019I -
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批准号:8752604
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项目类别:
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资助金额:$3.99万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Patterns of Care/Quality of Care Study - Diagnosis Year 2012; HHSN261201300009I T
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批准号:8749643
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项目类别:
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资助金额:$3.91万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Surveillance, Epidemiology, and End Results (SEER) Program
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批准号:8743666
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项目类别:
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资助金额:$363.03万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Patterns of Care/Quality of Care - Diagnosis Year 2012
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批准号:8752583
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项目类别:
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资助金额:$8.09万
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财政年份:2013
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负责人:Michael Pawlita
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依托单位:
Meeting Support for Applied Research Program
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批准号:8755668
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项目类别:
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资助金额:$9.0万
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财政年份:--
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负责人:Michael Pawlita
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依托单位:--
海外基金