ARDS - SAILS Protocol

ARDS - SAILS 协议

• 批准号: 8602442
• 负责人: BENNETT P DEBOISBLANC
• 金额: $ 7.41万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2013-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8602442
• 关键词: Acute Lung Injury; Adult Respiratory Distress Syndrome; Dose; Hospitals; Lung; Oral; Patients; Pharmaceutical Preparations; Placebos; Protocols documentation; Randomized; Research Design; Safety; Sepsis; injured; mortality; rosuvastatin

The purpose of the Statins for Acutely Injured Lungs from Sepsis (SAILS) protocol is to assess the efficacy and safety of oral rosuvastatin in patients with sepsis-induced Acute Lung Injury (ALI). Up to 1000 patients with ALI will be randomized in the study design. The first study drug dose (rosuvastatin or placebo) is 40 mg. Subsequent doses of 20 mg will be administered daily until 28 days after randomization or three days after ICU discharge (whichever occurs first), or discharge from study hospital. The study hypothesis is that the Rosuvastatin will reduce mortality The primary efficacy variable is mortality to study day 60.

他汀类药物治疗脓毒症急性肺损伤（SAILS）方案的目的是评估口服瑞舒伐他汀治疗脓毒症急性肺损伤（ALI）患者的有效性和安全性。