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The Mechanisms Involved in Chemotaxis of Immune and Cancer Cells

The Mechanisms Involved in Chemotaxis of Immune and Cancer Cells
免疫细胞和癌细胞趋化性的机制
批准号：
8556059
负责人：
Tian Jin
金额：
$33.67万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8556059
关键词：
ActinsCXCL12 geneCXCR4 ReceptorsCellsChemotaxisComplexCytoskeletonDockingGTP-Binding ProteinsGoalsHumanHuman bodyImmuneLinkMediatingMolecularNeoplasm MetastasisPathway interactionsPlayProcessProtein SubunitsReceptor SignalingRoleSignal Transductionbeta-arrestincancer cellcell motilitychemokinechemokine receptormigrationneutrophilnoveltrafficking

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英文摘要
We have two projects. 1. How does CXCR4 receptor signaling to Elmo/Dock complex leading to actin cytoskeleton? Our study in D. discoideum revealed a novel pathway linking G-protein subunits directly to Elmo/Dock complex. We are in the process to investigate whether this is evolutionarily conserved in chemokine receptor-controlled cell migration in human. 2. The role of beta- arrestin in neutrophil chemotaxis. It is known that activated chemokine GPCRs interact with beta-arrestin, which brings signaling components and activates pathways independent of G-proteins. It has been suggested that beta-arrestin signaling plays a role in cell migration, but the molecular mechanisms underlining this process are not known. We are in the process to study these mechanisms using neutrophils.
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The mechanisms underlying the GPCR-mediated chemotaxis in D. discoideum
The Mechanisms Involved in Chemotaxis of Immune and Cancer Cells
Using FRET to Probe the Spatial Distributions of CD4, CX
G-protein Coupled Receptor Mediated Directional Sensing