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Antiviral host defense through selective translational inhibition

Antiviral host defense through selective translational inhibition
通过选择性翻译抑制进行抗病毒宿主防御
批准号：
8473888
负责人：
MICHAEL DAVID
金额：
$28.42万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-06-01 至 2016-05-31
来源：
https://reporter.nih.gov/project-details/8473888
关键词：
AIDS/HIV problemATP phosphohydrolaseAffectAlternative SplicingAnti-Retroviral AgentsAntigensAntiviral AgentsAntiviral ResponseAreaAttenuatedBindingBiogenesisBiological ProcessCaenorhabditis elegansCellsChargeCodon NucleotidesCommunicable DiseasesDNADevelopmentDiagnosticDiseaseDominant-Negative MutationDrosophila genusERG geneEmployee StrikesEventFamilyGenerationsGenesGenetic TranscriptionGoalsHIVHIV InfectionsHomologous GeneHost DefenseHumanIRF3 geneImmune responseInfectionInfection preventionInfluenzaInterferon-alphaInterferon-betaInterferonsKineticsLengthLightLocationMediatingMessenger RNAMolecularMolecular Mechanisms of ActionMulti-Drug ResistanceMusN-terminalNucleic Acid BindingOrganismPathway interactionsPharmaceutical PreparationsPositioning AttributePoxviridaeProcessProductionProtein BindingProtein BiosynthesisProtein InhibitionProtein IsoformsProtein Synthesis InhibitionProteinsRNA HelicaseReportingRetroviridaeReverse TranscriptionRoleShapesSpecificityStagingSystemTestingTherapeuticTherapeutic InterventionTransfer RNATranslational RepressionViralViral ProteinsVirusYeastsbasemembermicrobialnovelpathogenpreferenceprognosticprospectiveprotein expressionprotein functiontoolviral RNA

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DESCRIPTION (provided by applicant): HIV continues to be one of the most prevalent infectious diseases in this world. Our discovery of a novel cellular factor that inhibits the production of HIV by infected cells provides a new target for the development of a novel class of anti-viral drugs and may additionally carry diagnostic and prognostic value. Furthermore, based on the molecular basis of the antiviral activity we hypothesize that other viruses such as Influenza will also be subject to inhibition by huSlfn11.
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Translational inhibition by Schlafen proteins during the DNA damage response
The IRF-type I interferon system during gestation
DNA structure modification by the Schlafen protein family
Role of TLR3 pathway in HIV infection