Discovery to Implementation & Back: Research Translation for the HIV/SU Epidemic

描述（由申请人提供）：这是药物使用和艾滋病毒研究中心的续期申请。我们这次更新的重点将是“从发现到实施再回来：艾滋病毒/物质流行病的研究翻译”。我们目前的中心专注于与艾滋病毒和药物使用有关的跨学科研究。在此期间，该中心的研究人员（目前分布在4个机构）有所增加，为协同和合作提供了新的机会，研究人员为该领域做出了许多重大贡献。然而，艾滋病毒的发病率、发病率和死亡率仍然高得令人无法接受，药物使用仍然是减少发病率和健康差距、获得护理和最大限度地利用护理惠益的一个重大障碍。药物使用者仍然极易受到伤害和侮辱，注重药物使用在这一流行病中的作用，对于我们实现《国家艾滋病毒/艾滋病战略》的目标（即减少新的感染、改善与艾滋病毒有关的健康结果和缩小与艾滋病毒有关的健康差距）至关重要。此外，有必要加快研究成果的转化过程（从发现转化为对公共卫生的影响），并纳入有关影响这一流行病的迅速变化的环境的知识，包括生物医学进展和社会经济变化。为了建立一个应对这些挑战的基础设施，我们在业务范围和核心结构上做出了重大改变。中心更新的总体目标是：(1)提高研究的质量和影响，以支持NHAS的目标；(2)加大项目科研翻译力度；(3)使项目能够纳入对影响艾滋病毒药物使用流行病的环境变化的研究。我们将通过6个核心来实现这些目标：一个行政核心和5个研究支持核心：(1)跨学科理论综合与发展；(2)传染病与生物医学；(3)跨学科研究方法；(4)比较有效性研究；(5)试点项目和指导。这些核心将致力于加强研究人员之间的协同作用和生产力，并刺激制定新的举措、新的研究人员和新的知识，以影响艾滋病毒药物使用流行病。

DESCRIPTION (provided by applicant): This is a renewal application for the Center for Drug Use and HIV Research. Our focus in this renewal will be "From Discovery to Implementation and Back: Research Translation for the HIV/Substance (SU) Epidemic". Our current Center focused on interdisciplinary research related to HIV and substance use. During this period the Center experienced a growth in investigators (now located at 4 institutions) that provided new opportunities for synergy and collaboration, and investigators made many significant contributions to the field. However, HIV incidence, morbidity and mortality remain at unacceptably high rates, and substance use remains a critical barrier to reducing incidence and health disparities, accessing care, and maximizing the benefits of care. Substance users remain highly vulnerable and stigmatized, and a focus on the role of substance use in the epidemic is vital to our achieving the goals of the National HIV/AIDS Strategy (NHAS) (i.e., to reduce new infections, improve HIV-related health outcomes and reduce HIV-related health disparities). In addition, there is a need to expedite the research translation process (from discovery to public health impact) and to incorporate knowledge about the rapidly changing contexts that impact the epidemic, including biomedical advances and socio-economic changes. To create an infrastructure to address these challenges, we have made significant changes in our scope and Core structure for this renewal. The overarching aims of this Center renewal are to: (1) enhance the quality and impact of research to support the goals of the NHAS; (2) enhance projects' research translation efforts; and (3) enable projects to incorporate the study of the contextual changes influencing the HIV-substance use epidemic. We will achieve these aims through 6 Cores: an Administrative Core and 5 Research Support Cores: (1) Transdisciplinary Theoretical Synthesis and Development; (2) Infectious Diseases and Biomedical; (3) Transdisciplinary Research Methods; (4) Comparative Effectiveness Research; and (5) Pilot Projects and Mentoring. These Cores will work to enhance synergy and productivity across investigators, and stimulate the development of new initiatives, new investigators and new knowledge to impact the HIV-substance use epidemic.