Core B: Behavioral Core

项目总结(见说明)： 行为核心将为本申请中提出的所有个别项目提供服务。除了监督项目中使用的所有动物的饲养，还有一些所有项目通用的行为测试程序，这些程序将在行为核心进行。这包括最初的行为测试，以量化被认为是导致上瘾易感性的“特征”，包括将激励突显归因于奖励线索的倾向(通过巴甫洛夫的奖励线索方法来衡量)和做出“冲动行动”的倾向(通过在两个选择的系列反应时间任务中的过早反应来衡量)。此外，在可行和适当的情况下，将在行为核心进行药物自我给药测试。行为核心的实施将确保一定程度的“质量控制”和标准化，这将大大减少差异，并便利比较各个项目的结果。

PROJECT SUMMARY (See instructions): The Behavioral Core will serve all individual Projects proposed in this application. In addition to the supervision of husbandry for all animals to be used in the Projects, there are a number of behavioral test procedures that are common to all Projects and these will be conducted in the Behavioral Core. This includes initial behavioral testing to quantify "traits" that are thought to contribute to vulnerability to addiction, including the propensity to attribute incentive salience to reward cues (measured by Pavlovian approach to reward cues) and the propensity to make "impulsive actions" (measured by premature responses on a 2-choice serial reaction time task). In addition, drug self-administration testing will be conducted in the Behavioral Core, when feasible and appropriate. The implementation of the Behavioral Core will insure a level of "quality control" and standardization that will significantly reduce variance and facilitate the comparison of results across individual Projects.