The Impact of Mobility on HIV Care in New York City and the Dominican Republic

流动性对纽约市和多米尼加共和国艾滋病毒护理的影响

• 批准号: 8306871
• 负责人: Barbara S Taylor
• 金额: $ 12.81万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-03 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306871
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Adherence; Affect; Africa South of the Sahara; Air; Anti-Retroviral Agents; Antiretroviral drug resistance; Antiretroviral resistance; Area; Basic Science; Behavior; Biostatistical Methods; Canada; Caring; Case-Control Studies; Chronic Disease; Cities; Clinic; Clinical Research; Collaborations; Communicable Diseases; Communities; Country; Data; Diagnosis; Dominican; Dominican Republic; Epidemic; Ethnography; Exposure to; Failure; Future; Goals; HIV; HIV-1; Health Services Accessibility; Healthcare; Height; Incidence; Individual; Institution; International; Interruption; Intervention; Interview; Investigation; Joints; Knowledge; Latino; Life; Link; Measures; Medical; Mentorship; Methods; Mexico; Minority; Motivation; New York; New York City; Nomads; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Pattern; Population; Portraits; Process; Prostitution; Recording of previous events; Regimen; Reporting; Research; Research Personnel; Resources; Review Literature; Risk; Risk Behaviors; Side; Site; Social support; Southeastern Asia; Specialist; Structure; Surveys; Techniques; Testing; Therapeutic; Time; Travel; Treatment Failure; Treatment outcome; Twin Multiple Birth; United Nations; United States National Institutes of Health; Virus Diseases; Washington; antiretroviral therapy; base; comparative; condoms; design; effective intervention; ethnographic method; evidence base; experience; follow-up; health care service utilization; improved; informant; innovation; instructor; migration; multidisciplinary; novel; patient population; programs; skills; social; success; treatment center

The candidate is an instructor in infectious diseases at Columbia University Medical Center (CUMC), and her long-term goal is to become an independent investigator studying the interaction between social and structural factors and HIV treatment outcomes in international and domestic Latino communities. Her short-term goals are to expand her experience in international research, refine her skills in biostatistical methods, and further the understanding of the interaction between mobility and HIV care outcomes in mobile communities. She has an extensive track record of basic science and clinical research, and has been building the framework for this project in the Dominican Republic (DR) for the past four years. CUMC sits at one end of the New York-Dominican Republic air-bridge, a pattern of circular migration between the two countries. Our goal is to understand the interactions between mobility and HIV treatment amongst Dominicans in our own HIV treatment center in Washington Heights, New York (WH), and in Santo Domingo (SD), DR. Our primary hypothesis is that individual mobility leads to interruptions in antiretroviral therapy, and, in turn, to antiretroviral treatment failure. We will undertake a qualitative assessment of mobility using comparative ethnography in the Dominican pafient population at both sites (WH and SD), and use that knowledge to develop a community-appropriate and evidence based measure of mobility. We will then conduct case-control studies to assess mobility as a predictor of treatment failure at both sites. We will also examine differences in those failing with and without antiretroviral drug resistance. This research will take place at CUMC and collaborafing institutions in the DR with the mentorship of Dr. Scott Hammer, an internationally recognized HIV investigator. Dr. Jennifer Hirsch, a specialist in HIV and migration, and Dr. Louise Kuhn, an expert in HIV treatment outcomes in resource-limited settings. CUMC serves the largest community of Dominicans outside of the DR, and the collaborating institutions in the DR have long histories of successful clinical research and existing research initiatives with CUMC.

这位候选人是哥伦比亚大学医学中心（CISC）传染病的讲师，她的研究成果包括： 长期目标是成为一名独立的研究者，研究社会和 结构因素和艾滋病毒治疗结果在国际和国内拉丁美洲社区。她的短期 目标是扩大她在国际研究方面的经验，提高她在生物统计方法方面的技能， 并进一步了解移动的环境中的流动性与艾滋病毒护理结果之间的相互作用 社区.她在基础科学和临床研究方面拥有广泛的记录，并一直 在过去的四年里，多米尼加共和国为该项目建立了框架。 哥伦比亚特区位于纽约-多米尼加共和国空中桥梁的一端，这是一种循环移民模式 加强两国我们的目标是了解流动性和艾滋病治疗之间的相互作用 我们在华盛顿高地、纽约（WH）和圣多的艾滋病治疗中心的多米尼加人中， 我们的主要假设是，个体的流动性导致抗逆转录病毒治疗的中断。 治疗，反过来，抗逆转录病毒治疗失败。我们将对流动性进行定性评估 在两个地点（WH和SD）的多米尼加患者人群中使用比较民族志，并使用 知识，以制定一个适合社区和基于证据的流动措施。然后我们将 进行病例对照研究，以评估活动性作为两个地点治疗失败的预测因素。我们还将 检查那些没有抗逆转录病毒药物耐药性的失败者的差异。 这项研究将发生在CNOC和合作机构在DR与博士的指导。 Scott Hammer是一位国际知名的HIV研究者。詹妮弗·赫希博士，艾滋病专家， 移民，以及资源有限环境下艾滋病毒治疗结果专家路易丝·库恩博士。CUMC 服务于多米尼加共和国以外最大的多米尼加人社区，以及多米尼加共和国的合作机构 具有长期成功的临床研究历史和现有的研究计划与CMEC。