Targeted Monitoring and Determinants of Adherence in Adolescents with HIV

艾滋病毒青少年依从性的有针对性的监测和决定因素

• 批准号: 8542894
• 负责人: Elizabeth Dawn Lowenthal
• 金额: $ 17.48万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-10 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8542894
• 关键词: Address; Adherence; Adolescence; Adolescent; Adolescent Behavior; Adolescent Medicine; Adult; Africa South of the Sahara; Aging; Anthropology; Area; Award; Behavior; Behavioral; Biometry; Botswana; Caregivers; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Childhood; Chronic Disease; Clinical; Clinical Psychology; Cognitive; Consumption; Data; Dependence; Development; Disease Progression; Effectiveness; Electronics; Expectancy; Failure; Family; Functional disorder; Future; Grant; HIV; Health; Health behavior; Immune system; Individual; International; Intervention; Interview; K-Series Research Career Programs; Knowledge; Lead; Life; Measurable; Measurement; Measures; Medical; Mentors; Mentorship; Methods; Modeling; Monitor; Outcome; Parents; Patient Self-Report; Patients; Pharmaceutical Preparations; Pharmacy facility; Population; Psychosocial Factor; Psychosocial Influences; Public Health; Relative (related person); Reporting; Research; Research Ethics; Research Personnel; Research Training; Resistance; Resources; Risk Factors; Sampling; Series; Site; Social Desirability; Supervision; Symptoms; Testing; Time; Training; Treatment Failure; Treatment outcome; Validation; Viral Load result; Virus; Work; Youth; antiretroviral therapy; base; career; clinical epidemiology; cost; experience; improved; innovation; medication compliance; novel; psychologic; psychosocial; restoration; screening; sex risk; skills; social; social stigma; success; successful intervention; theories; tool; treatment adherence; young adult

DESCRIPTION (provided by applicant): The candidate for this K23 Career Development Award aims to become an independent investigator whose work will lead to successful interventions to promote adherence among HIV-infected (HIV+) adolescents, particularly in resource-limited settings. HIV+ adolescents have poor adherence to antiretroviral therapy relative to both adults and younger children. This is of paramount importance in sub-Saharan Africa where about 90% of HIV-infected youth live and where treatment options are limited. For HIV+ adolescents, poor adherence is commonly their greatest barrier to long-term treatment success. In addition, low-cost monitoring strategies such as patient self-report are often less reliable in adolescents. The proposed research will determine whether simply assessed adolescent characteristics can be used to target the choice of low-cost adherence monitoring strategies for individual adolescents. It will also clarify the impact of key potentially modifiabl risk factors on treatment adherence in adolescents, demonstrating targets for future interventional studies to support adherence among adolescents in resource-limited settings. The candidate for this award has a strong background in pediatric and adolescent treatment in resource-limited settings, having worked full-time in Botswana for 4 years as the Associate Director of the Botswana-Baylor Children's Clinical Centre of Excellence (COE). The COE has provided care and treatment to over 2000 HIV+ children and adolescents and is the study site for the K23 research. In addition to her extensive experience in pediatric and adolescent HIV care in resource-limited settings, the candidate for this award has undergone training in clinical epidemiology and is the PI for a CDC Public Health Effectiveness Grant evaluating other aspects of adherence among adolescents in a resource-limited setting. The candidate's primary mentor is Dr. Robert Gross. Dr. Gross is an international expert in HIV adherence research and has an outstanding track record of mentorship. Drs. Steven Feierman, Karen Glanz, Wei-Ting Hwang and Seipone Mphele will serve as co-mentors in the areas of medical anthropology, health behavior, biostatistics, and clinical psychology, respectively. The proposed training and mentorship will provide the candidate with the skills and experience necessary to support her development as a successful independent researcher. The K23 research and training plan will expand her expertise into the areas of behavioral theory, test construction and validation, qualitative and longitudinal analyses, and international research ethics.

描述（由申请人提供）：K23 职业发展奖的候选人旨在成为一名独立调查员，其工作将导致成功的干预措施，以促进艾滋病毒感染 (HIV+) 青少年的依从性，特别是在资源有限的环境中。 HIV+ adolescents have poor adherence to antiretroviral therapy relative to both adults and younger children.这对于撒哈拉以南非洲地区至关重要，那里生活着大约 90% 的艾滋病毒感染青年，而且治疗选择有限。 For HIV+ adolescents, poor adherence is commonly their greatest barrier to long-term treatment success.此外，患者自我报告等低成本监测策略在青少年中通常不太可靠。拟议的研究将确定是否可以使用简单评估的青少年特征来为青少年个体选择低成本的依从性监测策略。它还将阐明关键的潜在可改变风险因素对青少年治疗依从性的影响，展示未来干预研究的目标，以支持资源有限环境中青少年的依从性。该奖项的候选人在资源有限的环境下的儿科和青少年治疗方面拥有丰富的背景，曾在博茨瓦纳全职工作了 4 年，担任博茨瓦纳贝勒儿童临床卓越中心 (COE) 的副主任。 COE 已为 2000 多名 HIV+ 儿童和青少年提供护理和治疗，也是 K23 研究的研究地点。除了在资源有限环境中的儿科和青少年艾滋病毒护理方面拥有丰富的经验外，该奖项的候选人还接受过临床流行病学培训，并且是 CDC 公共卫生有效性补助金的 PI，该项目评估资源有限环境中青少年依从性的其他方面。候选人的主要导师是罗伯特·格罗斯博士。格罗斯博士是艾滋病毒依从性研究领域的国际专家，并拥有出色的指导记录。博士。 Steven Feierman、Karen Glanz、Wei-Ting Hwang 和 Seipone Mphele 将分别担任医学人类学、健康行为、生物统计学和临床​​心理学领域的联合导师。拟议的培训和指导将为候选人提供必要的技能和经验，以支持她成为一名成功的独立研究员。 K23 研究和培训计划将把她的专业知识扩展到行为理论、测试构建和验证、定性和纵向分析以及国际研究伦理领域。