Behavior Problems in Infancy: A Preventive Intervention

该指导以患者为导向的研究职业发展奖（K23）的目标是为Bagner博士准备独立的临床研究职业生涯，专注于为婴儿及其家庭制定预防干预措施。Bagner博士的长期职业目标是开发一个跨学科的研究项目，研究针对有外化行为问题风险的婴儿的有效干预措施，并帮助推进针对有其他行为和情绪问题的婴儿的循证实践。在K23培训计划的背景下，Bagner博士的短期培训目标是：（1）获得关于婴儿发育独特过程的专门培训，包括典型和高危人群，以及基于关系的干预措施的性质;（2）获得设计、执行和分析对婴儿及其家人进行家庭预防试验的知识和专业知识;以及（3）扩大对与低收入家庭进行干预研究相关的伦理和多元文化问题的理解。这一培训计划将得到以下方面的协助：（a）Wendy Silverman、巴里莱斯特、大卫奥尔兹、Lorraine Bahrick、Alice Carter、James Jaccard、William Pelham和Jose Rosa-Olivares博士的专家指导;（B）正式课程和研讨会;（c）指导阅读;（d）婴儿心理健康领域的重点临床经验;（e）佛罗里达国际大学及迈阿密儿童医院可提供的各种资源;及（f）推行拟议的研究计划。Bagner博士将实施一项为期5年的研究，在这项研究中，他将开发和评估一种预防性干预措施对有外化行为问题风险的婴儿的潜在疗效。干预措施将是对家庭环境中用于婴儿的亲子互动疗法的调整（即，PCIT-I）。拟议合同的前18个月将用于开发PCIT-I并在公开试验中进行试点。随后，Bagner博士将进行一项小型随机试验，将PCIT-I与标准治疗进行比较。关于PCIT-I的可行性和可接受性以及结果的临床意义的数据，结合统计分析的结果，将用于通知II期临床试验的R 01申请。

DESCRIPTION (provided by applicant): The goal of this Mentored Patient-Oriented Research Career Development Award (K23) is to prepare Dr. Bagner for an independent clinical research career focused on developing preventive interventions for infants and their families. Dr. Bagner's long-term career goals are to develop a transdiciplinary research program examining effective interventions for infants at risk for externalizing behavior problems and help advance evidence-based practice for infants with other behavioral and emotional problems. In the context of the K23 training plan, Dr. Bagner's short-term training goals are to: (1) acquire specialized training in the unique processes of infant development, including typical and at-risk populations, and the nature of relationship-based interventions; (2) gain knowledge and expertise in the design, execution, and analysis of conducting home- based prevention trials with infants and their families; and (3) broaden understanding of ethical and multicultural issues relevant to conducting intervention research with low-income families. This training plan will be facilitated by: (a) expert mentorship from Drs. Wendy Silverman, Barry Lester, David Olds, Lorraine Bahrick, Alice Carter, James Jaccard, William Pelham, and Jose Rosa-Olivares; (b) formal coursework and seminars; (c) directed readings; (d) focused clinical experiences in the area of infant mental health; (e) the diverse resources available at Florida International University and Miami Children's Hospital; and (f) implementation of the proposed research project. Dr. Bagner will implement a 5-year research study in which he will develop and evaluate the potential efficacy of a preventive intervention for infants at risk for externalizing behavior problems. The intervention will be an adaptation of Parent-Child Interaction Therapy for use with infants in the home setting (i.e., PCIT-I). The first 18 months of the proposed award will be devoted to developing PCIT-I and piloting it in an open trial. Subsequently, Dr. Bagner will conduct a small randomized trial comparing PCIT-I to standard care. Data concerning the feasibility and acceptability of PCIT-I and clinical significance of findings, combined with results from statistical analyses, will be used to inform an R01 application for a stage II clinical trial.