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Prenatal stress and the development of inhibitory neurons in the forebrain

产前应激和前脑抑制性神经元的发育

基本信息

批准号：
8485675
负责人：
HANNA E STEVENS
金额：
$ 17.01万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8485675
关键词：
Acute Address Adolescent Adult Affect Amygdaloid structure Animal Model Animals Anxiety Apoptotic Area Award Behavior Behavior Disorders Behavioral Brain Brain-Derived Neurotrophic Factor Cell Count Cell Death Cell Maturation Cells Child Childhood Clinical Clinical Research Data Development Development Plans Disease Doctor of Philosophy Educational workshop Electrophysiology (science)Embryo Event Functional disorder Funding Gilles de la Tourette syndrome Goals Green Fluorescent Proteins Growth Factor Hippocampus (Brain)Human Hypothalamic structure In Situ Hybridization Individual Intervention K-Series Research Career Programs Laboratories Learning Limbic System Link Measures Medial Mediating Mediator of activation protein Mental disorders Mentors Molecular Mus Neonatal Neuroanatomy Neurobiology Neurons Neurosciences Neurosciences Research Neurosecretory Systems Parvalbumins Patients Performance Phenotype Population Prefrontal Cortex Pregnancy Pregnant Women Property Prosencephalon Psychiatric therapeutic procedure Psychiatry Recruitment Activity Regulation Research Research Proposals Schizophrenia Slice Somatostatin Staging Stem cells Stress Structure Survival Analysis System Techniques Time Training United States National Institutes of Health Western Blotting Work base calretinin career career development cholinergic cingulate cortex depressive symptoms design developmental neurobiology experience functional outcomes gamma-Aminobutyric Acid in vitro activity in vivo inhibitory neuron interest knowledge base mature animal migration neurobiological mechanism neurodevelopment neuron development offspring postnatal prenatal prenatal exposure prenatal stress programs promoter research study response septohippocampal skills social symposium transcription factor

项目摘要

DESCRIPTION (provided by applicant: This application presents a career development award that integrates clinical child and adult psychiatry, animal models of developmental neuroscience, and stress neurobiology. The immediate goal is to create a program investigating the developmental mechanisms of the neurobiological effects of prenatal stress, focused on inhibitory neurons. The long term objective is to contribute to the understanding of early developmental events that contribute to severe childhood and adult psychiatric illness, the pathophysiology that underlies disorders such as schizophrenia and Tourette syndrome, and how interventions can modify early developmental changes. The candidate completed a Ph.D. in neuroscience with individual NIH funding and has now been involved in comprehensive training in clinical and research psychiatry for the past 5 years at the Yale Child Study Center (YCSC) and Department of Psychiatry. This award will provide critical support for the continuation of her integrated research in the YCSC Developmental Neurobiology Laboratory and the transition to an independent career in basic developmental neuroscience within the framework of understanding child and adult psychiatric illness. In the research proposal, an animal model of prenatal stress will be used to study the mechanisms of widespread, persistent effects on CNS structure and function. GABAergic systems will be the focus of the research plan, as patients with schizophrenia and other behavioral disorders linked to prenatal stress in humans have abnormal GABAergic neuron populations. Dr. Stevens will complete the first stage of the research plan on the anatomical effects of prenatal stress on inhibitory neurons with the support of this award and the skills she has developed in her postdoctoral work. She will then go on to make assessments of molecular mechanisms of prenatal stress affecting GABAergic populations both during the embryonic time period and during adult development. Functioning of inhibitory neuronal systems will be examined with behavioral and electrophysiological measures. This experimental work also comprises the career development plan for this candidate to obtain the necessary skills for an independent career in basic neuroscience research that can investigate important questions about the neurodevelopment of mental illness. The candidate has recruited an outstanding group of mentors and advisors that will guide the research plan in design, performance of experiments, and analysis of results. For career development, this mentor and advisor team will continue to support the candidate as she develops an independent laboratory program at the YCSC relevant to the neurodevelopment of mental illness and as she pursues additional training in molecular, behavioral, and electrophysiological techniques through coursework, intensive workshops and national conferences.

描述（由申请人提供：此应用程序提出了一个职业发展奖，整合临床儿童和成人精神病学，发育神经科学的动物模型，和压力神经生物学。目前的目标是建立一个程序，调查产前压力的神经生物学影响的发育机制，重点是抑制性神经元。长期目标是帮助理解导致严重儿童和成人精神疾病的早期发育事件，精神分裂症和抽动秽语综合征等疾病的病理生理学，以及干预措施如何改变早期发育变化。候选人完成了博士学位。在过去的5年里，他一直在耶鲁儿童研究中心（YCSC）和精神病学系参与临床和研究精神病学的综合培训。该奖项将为她在YCSC发育神经生物学实验室的综合研究的继续提供关键支持，并在理解儿童和成人精神疾病的框架内过渡到基础发育神经科学的独立职业生涯。在这项研究计划中，将使用产前应激的动物模型来研究对中枢神经系统结构和功能的广泛、持续影响的机制。GABA能系统将是研究计划的重点，因为患有精神分裂症和其他与人类产前应激有关的行为障碍的患者具有异常的GABA能神经元群体。史蒂文斯博士将在该奖项的支持下，利用她在博士后工作中开发的技能，完成产前压力对抑制性神经元的解剖学影响研究计划的第一阶段。然后，她将继续评估产前应激影响胚胎期和成人发育期间GABA能群体的分子机制。抑制性神经元系统的功能将通过行为和电生理测量进行检查。这项实验工作还包括该候选人的职业发展计划，以获得在基础神经科学研究中独立职业的必要技能，该研究可以调查有关精神疾病神经发育的重要问题。候选人已经招募了一批优秀的导师和顾问，他们将指导研究计划的设计，实验性能和结果分析。对于职业发展，这个导师和顾问团队将继续支持候选人，因为她在YCSC开发了一个独立的实验室项目，与精神疾病的神经发育相关，并且她通过课程，密集的研讨会和全国会议追求分子，行为和电生理技术的额外培训。