Training in Trauma and Burn Research

描述(由申请者提供)：该培训计划的目标是准备年轻的研究人员在创伤科学领域进行临床适用和转化性研究。该项目设在芝加哥洛约拉大学的烧伤和休克创伤研究所，这是一个独特的高度协作的研究环境，有50多人参与，其中包括7名首席研究员、4名额外的科学教员、5名创伤和危重护理临床专家、8名博士后研究员(包括医学博士和博士)、9名研究生、2名研究护士、6名研究技术人员和2名支持人员。该计划向住院医师和博士后征集申请，以进入为期两年的创伤学高强度研究培训阶段。该计划自2000年开始实施，目前每年接受一名新学员，下一个周期的目标是将该计划扩大到包括每年任命两名新学员。其中包括我们在地方和国家两级的努力，以及促进在学校、本科生和医学院各级为少数民族青年学生提供教育和指导机会的全面计划。受训人员可以从七名不同的主要研究人员中进行选择，他们都是创伤相关研究的导师，包括1)创伤后的骨髓细胞变化，2)酒精引起的烧伤和脓毒症后的免疫变化，3)衰老中的免疫调节，4)伤口愈合和血管修复，5)酒精引起的骨矿代谢和骨折愈合的变化，以及6)创伤生物学中的泛素-蛋白小体系统。培训计划强调每个受训者与他们的导师之间的密切工作关系，包括实验室研究、研讨会、期刊俱乐部、赠款撰写培训以及统计学和研究生物伦理学的教学课程。所有受训人员都需要书面研究建议书、正式的研究报告和每半年一次的评估。为了培养对临床问题的认识，博士实习生参加选定的临床会议，并在规定的时间段参加创伤和烧伤服务的查房。我们的长期目标是增加临床医生和博士科学家的数量，他们有资格和有动力共同努力，解决过渡性创伤研究中的基本问题。相关性：创伤造成的生命和生产力损失是国家一级的主要社会问题之一。了解创伤生物学，以提高对重伤患者的护理标准，是我们减少创伤对社会的影响从而提高国家生产力的战斗中的一个基本要素。培训未来的临床医生谁将照顾创伤患者的创伤生物学/将导致新的干预和治疗策略的危重患者。

DESCRIPTION (provided by applicant): The goal of this training program is to prepare young investigators to perform clinically applicable and translational research in the field of trauma science. The program is based at the Burn and Shock Trauma Institute of Loyola University in Chicago, a unique, highly collaborative research environment that includes more than 50 people, including seven principle investigators, four additional scientific faculty, five clinical specialists in trauma and critical care, eight post-doctoral fellows (both MDs and Ph.D.s), nine graduate students, two research nurses, six research technicians, and two support staff. The program solicits applications from resident physicians and post-doctoral Ph.D.s to enter a two-year period of intense research training in traumatology. The program, which has been in place since 2000, currently accepts one new trainee each year, and a goal for the next cycle is to expand the program to include the appointment of two new trainees each year. A specific plan for the recruitment of underrepresented minorities, which includes our efforts at local and national levels and a comprehensive plan to promote educational and mentorship opportunities for young minority students at school, undergraduate and medical school levels are provided. Trainees are allowed to select from among seven different principal investigators who are each experienced mentors in trauma-related research, including 1) myelopoietic alterations after injury, 2) alcohol induced immune changes following burn and sepsis, 3) immune regulation in aging, 4) wound healing and vascular repair, 5) alcohol induced changes in bone mineral metabolism and fracture healing and 6) ubiquitin- proteosome system in trauma biology. The training plan emphasizes a close working relationship between each trainee and their mentor, and includes laboratory research, seminars, journal clubs, training in grant writing, and didactic coursework in both statistics and research bioethics. Written research proposals, formal research presentations, and semi-annual evaluations are required of all trainees. To develop an appreciation for clinical problems, Ph.D. trainees participate in selected clinical conferences and attend rounds on the Trauma and Burn Services during defined periods. Our long-term goal is to increase the number of clinicians and Ph.D. scientists who are qualified and motivated to work together to address fundamental questions in transitional trauma research. RELEVANCE: Loss of life and productivity due to trauma is one of the major societal problems at the national level. Understanding the biology of traumatology to improve the standard of care of the critically injured patients is an essential element in our battle to reduce the impact of trauma on society and thus improve national productivity. Training future clinicians who will take care of trauma patients in the science of trauma biology /will lead to new interventional and therapeutic strategies to the critically injured patients.