课题基金 / 基金详情

Protein secretion pathways in the phylum Bacteroidetes

Protein secretion pathways in the phylum Bacteroidetes
拟杆菌门中的蛋白质分泌途径
批准号：
8741626
负责人：
Harris Bernstein
金额：
$32.62万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741626
关键词：
AddressBacteroides fragilisBacteroidetesBioinformaticsCell surfaceComputer SimulationEscherichia coliHumanInflammatory Bowel DiseasesLarge IntestineMaintenanceMass Spectrum AnalysisMembraneMembrane ProteinsMethodsOral cavityOrganismPathway interactionsPeriodontal DiseasesPhysiologyPlayPorphyromonas gingivalisProtein SecretionProteinsProteobacteriaProteomeRoleSystemTechnologyTissuesbasegenome sequencinginsightmembermicrobiomemicroorganismnoveloral microbiomeprotein expression

项目摘要

项目成果

Harris Bernstein的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Bacteroides fragilis is an abundant constituent of the human gut microbiome that presumably uses cell surface and secreted molecules to colonize the host and interact with other microorganisms. Although many outer membrane proteins can be predicted from the genome sequence by bioinformatic methods, the expression of these proteins under different conditions has not been examined. Furthermore, outer membrane proteins that have unusual features and proteins that are secreted by novel mechanisms cannot be identified by in silico methods. To address these issues, we are currently analyzing the outer membrane proteome and secretome of B. fragilis using multidimensional protein identification technology (MudPIT) and other mass spectrometry-based methods.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Translational regulation in the ribosome tunnel
Biogenesis of bacterial autotransporter proteins
Translational regulation in the ribosome tunnel
Biogenesis of bacterial outer membrane proteins
国内基金
海外基金
Bacteroides fragilis通过3-oxoLCA诱导FBXO38介导的PD-1泛素化降解改善结直肠癌免疫治疗效果的机制研究
  • 批准号：
    --
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    --
  • 批准年份：
    2024
  • 负责人：
    邵欣宇
  • 依托单位：
    苏州市立医院