SBIR Topic 74, Phase I, RBC Storage System to Minimize Storage Lesions

该项目的目标是开发一种新颖、低成本的血液储存系统，该系统将提供更高质量的红细胞（RBC），从而减少输血治疗的有害后果。红细胞耗尽了O2和CO2，并在耗尽的条件下储存。所储存的红细胞显示出更高的疗效和更低的毒性。该产品被设计成易于集成到现有的血库操作实践中，只需对程序、设备或成本进行最小的更改。本合同的目的是设计和测试能够满足商业释放产品成本限制（成本和产品保质期）的原型预储存O2/CO2耗尽装置和厌氧储存袋的可行性。一个原型厌氧红细胞转化试剂盒将制造和基准测试。

The goal of this project is to develop a novel, low cost blood storage system that will and deliver red blood cells (RBC) of higher quality thereby reducing the harmful consequences of transfusion therapy. RBC are depleted of O2 and CO2 and stored under depleted condition. The stored RBC have shown higher efficacy and lower toxicity. The product is designed to be easily integrated into existing blood bank operating practices with minimal alteration in procedures, equipment or cost. The objective of this contract is to design and test the feasibility of a prototype pre-storage O2/CO2 depletion device and anaerobic storage bag capable of meeting a the cost constraints of a commercial release product (cost and product shelf life). A prototype anaerobic red blood cell conversion kit will be fabricated and benchtested.