Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
女性研究和指导计划中独特的心血管危险因素
基本信息
- 批准号:8427358
- 负责人:
- 金额:$ 19.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-01 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAffectAfrican AmericanAgreementAlaska NativeAmputationAngiotensin IIAnimalsAsiansAwardBehavior TherapyBehavioralBlindnessBlood VesselsCardiovascular DiseasesCardiovascular systemCaringCause of DeathChronicClinicalCollaborationsCommunitiesCommunity Health CentersComplications of Diabetes MellitusConjugated Equine EstrogensCross-Over StudiesDevelopmentDiabetes MellitusDiabetes preventionEnd stage renal failureEstradiolEstrogen ReplacementsEstrogen TherapyEstrogensEvaluationFDA approvedFall preventionForearmFunctional disorderGestational DiabetesGoalsGrantHealthHeartHeart DiseasesHispanicsHormone replacement therapyHormonesHospitalsHot flushesHypertensionIncidenceIndividualInjuryInterventionKidneyLimb structureMassachusettsMediatingMediator of activation proteinMedroxyprogesteroneMenopauseMentorsMessenger RNAMineralocorticoid ReceptorMinorityMorbidity - disease rateMyocardial InfarctionNative AmericansNeonatalNon-Insulin-Dependent Diabetes MellitusOutcomePatientsPostmenopausePostpartum PeriodPostpartum WomenPregnancyPreventionPrevention strategyProgesteroneProgestinsProspective StudiesPublic HealthQuality of lifeRandomizedRecommendationRecording of previous eventsRegimenRenal Blood FlowRenin-Angiotensin-Aldosterone SystemReportingResearchResearch PersonnelResearch Project GrantsRiskRisk FactorsRisk ReductionRodentSamplingStrokeSymptomsSystemTimeTranslatingTranslational ResearchTranslationsVasodilationVasomotorWeightWomanWomen&aposs Healthabstractingbasebrachial arterycardiovascular disorder riskcardiovascular risk factorclinical carecommunity settingdiabetes prevention programdrospirenonefallshigh riskimprovedkidney cortexlifestyle interventionpatient oriented researchpreclinical studypreventprogramspublic health relevancereceptor
项目摘要
DESCRIPTION (provided by applicant): This project has as its goal the mentoring of junior investigators in patient-oriented research through my research program in unique cardiovascular risk factors in women. Mentoring Goal: To maintain my mentoring program in patient-oriented research, continue to increase the number of women and minorities who enter this field and allow my program to further develop within the Harvard CTSA. The K24 will enable me to achieve these goals by allowing me to maintain the decrease in clinical care and administrative time that I achieved with the original K 24 award. Research Projects: This application is based on two translational research projects: 1) The determination of whether a progestin with antimineralocorticoid activity can ameliorate or prevent estrogen-induced cardiovascular complications in postmenopausal women. For many postmenopausal women, vasomotor symptoms are a major cause of decreased quality of life. Estrogen is the only FDA approved treatment for these symptoms. Recent studies have shown that estrogen increases risk for cardiovascular disease (CVD). Therefore, a safer way to provide such therapy is in need. We have shown that estrogen increases renin-angiotensin-aldosterone system activity, a major mediator of vascular dysfunction and that this increase is associated with a fall in renal blood flow. We have also shown that estrogen increases vascular damage and mRNA for the mineralocorticoid receptor. We postulate that drospirenone, a progestin, with antimineralocorticoid activity similar to progesterone, given with estrogen will decrease adverse vascular effects of traditional hormone replacement (estrogen + medroxyprogesterone). 2) The determination of whether the Diabetes Prevention Program (DPP) can be translated into the community setting for women with a history of gestational diabetes (GDM) to reduce the risk of progression to Type 2 diabetes (T2DM). T2DM is a major risk factor for CVD, particularly in women. Women with prior GDM have a high risk of progression to T2DM. The DPP demonstrated that lifestyle modification can decrease the risk for T2DM. We postulate that a modified DPP delivered in a community setting will be effective in decreasing postpartum weight retention in women with recent GDM.
描述(由申请人提供):该项目的目标是指导初级研究人员通过我的研究计划在女性独特的心血管危险因素中进行以患者为导向的研究。指导目标:为了保持我在以病人为导向的研究中的指导计划,继续增加进入这一领域的妇女和少数民族的人数,并允许我的计划在哈佛CTSA内进一步发展。K24将使我能够实现这些目标,让我保持减少临床护理和行政时间,我实现了与原来的K 24奖。研究项目:本申请基于两个转化研究项目:1)确定具有抗盐皮质激素活性的雷公藤红素是否可以改善或预防绝经后妇女中雌激素诱导的心血管并发症。对于许多绝经后女性来说,血管舒缩症状是生活质量下降的主要原因。雌激素是FDA批准的唯一治疗这些症状的药物。最近的研究表明,雌激素增加心血管疾病(CVD)的风险。因此,需要一种更安全的方法来提供这种治疗。我们已经发现雌激素增加了血管功能障碍的主要介质--肾素-血管紧张素-醛固酮系统的活性,这种增加与肾血流量的下降有关。我们还发现雌激素增加血管损伤和盐皮质激素受体的mRNA。我们假设屈螺酮(一种具有与孕酮相似的抗盐皮质激素活性的雌激素)与雌激素联合给药可减少传统激素替代(雌激素+甲羟孕酮)的不良血管效应。2)确定糖尿病预防计划(DPP)是否可以转化为有妊娠糖尿病(GDM)病史的女性的社区环境,以降低进展为2型糖尿病(T2 DM)的风险。2型糖尿病是心血管疾病的主要危险因素,尤其是在女性中。既往患有GDM的女性进展为T2 DM的风险较高。DPP表明,改变生活方式可以降低T2 DM的风险。我们假设,修改后的DPP交付在社区环境中将有效地减少产后体重保持在近期GDM的妇女。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ellen W Seely其他文献
General practitioners' knowledge about pregnancy complications associated with long-term cardiovascular risk.
全科医生对与长期心血管风险相关的妊娠并发症的了解。
- DOI:
10.24875/gmm.20000064 - 发表时间:
2021 - 期刊:
- 影响因子:0.8
- 作者:
M. Lumbreras;M. A. D. L. Torre;J. L. Hernández;Louise Wilkins;Ellen W Seely - 通讯作者:
Ellen W Seely
Guidelines Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative
先天性肾上腺增生症综合护理中心发展指南:CARES 基金会倡议的指导
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
R. Auchus;S. F. Witchel;Kelly R. Leight;Javier Aisenberg;Ricardo Azziz;T. Bachega;Linda A. Baker;Arlene B. Baratz;Laurence S. Baskin;Sheri A. Berenbaum;D. T. Breault;B. Cerame;Gerard S. Conway;Erica A. Eugster;Stephanie Fracassa;J. Gearhart;Mitchell E. Geffner;K. Harris;Richard S. Hurwitz;A. Katz;Brinda N. Kalro;Peter A. Lee;Gretchen Alger Lin;Karen J. Loechner;Ian Marshall;Deborah P. Merke;C. Migeon;Walter L. Miller;Tamara L. Nenadovich;Sharon E. Oberfield;K. Pass;D. Poppas;M. Lloyd;C. Quigley;F. Riepe;Richard C. Rink;S. Rivkees;David E Sandberg;Traci L. Schaeffer;R. Schlussel;F. Schneck;Ellen W Seely;Diane Snyder;Phyllis W. Speiser;B. Therrell;C. VanRyzin;M. Vogiatzi;M. Wajnrajch;Perrin C. White;Alan E. Zuckerman - 通讯作者:
Alan E. Zuckerman
Safety of GLP-1 Receptor Agonists and Other Second-Line Antidiabetics in Early Pregnancy
GLP-1 受体激动剂和其他二线抗糖尿病药物在妊娠早期的安全性
- DOI:
10.1001/jamainternmed.2023.6663 - 发表时间:
2023 - 期刊:
- 影响因子:39
- 作者:
C. Cesta;Ran S Rotem;B. T. Bateman;Gabriel Chodick;Jacqueline M. Cohen;Kari Furu;M. Gissler;K. Huybrechts;L. Kjerpeseth;M. Leinonen;Laura Pazzagli;H. Zoega;Ellen W Seely;Elisabetta Patorno;S. Hernández - 通讯作者:
S. Hernández
Cardiology patient page. Chronic hypertension in pregnancy.
心脏病学患者页面。
- DOI:
10.1161/circulationaha.106.636472 - 发表时间:
2007 - 期刊:
- 影响因子:37.8
- 作者:
Ellen W Seely;Cynthia Maxwell - 通讯作者:
Cynthia Maxwell
Edinburgh Research Explorer Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative
爱丁堡研究探索者先天性肾上腺增生综合护理中心发展指南:CARES 基金会倡议的指导
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
R. Auchus;Selma FeldmanWitchel;Kelly R. Leight;Javier Aisenberg;Ricardo Azziz;T. Bachega;Linda A. Baker;Arlene B. Baratz;Laurence S. Baskin;Sheri A. Berenbaum;D. T. Breault;B. Cerame;Gerard S. Conway;Erica A. Eugster;Stephanie Fracassa;J. P. Gearhart;Mitchell E. Geffner;K. Harris;Richard S. Hurwitz;A. Katz;Brinda N. Kalro;Peter A. Lee;Gretchen Alger Lin;Karen J. Loechner;IanMarshall;Deborah P. Merke;C. Migeon;Walter L. Miller;Tamara L. Nenadovich;Sharon E. Oberfield;K. Pass;D. Poppas;Michele A. Lloyd;C. Quigley;F. Riepe;Richard C. Rink;S. Rivkees;David E Sandberg;Traci L. Schaeffer;R. Schlussel;Francis X. Schneck;Ellen W Seely;Diane Snyder;Phyllis W. Speiser;B. Therrell;C. VanRyzin;M. Vogiatzi;Michael P. Wajnrajch;Perrin C. White;Alan E. Zuckerman - 通讯作者:
Alan E. Zuckerman
Ellen W Seely的其他文献
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{{ truncateString('Ellen W Seely', 18)}}的其他基金
Angiotensin II sensitivity, vascular dysfunction and prior preeclampsia
血管紧张素 II 敏感性、血管功能障碍和先兆子痫
- 批准号:
8916215 - 财政年份:2014
- 资助金额:
$ 19.95万 - 项目类别:
Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
女性研究和指导计划中独特的心血管危险因素
- 批准号:
8265868 - 财政年份:2010
- 资助金额:
$ 19.95万 - 项目类别:
Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
女性研究和指导计划中独特的心血管危险因素
- 批准号:
7787959 - 财政年份:2010
- 资助金额:
$ 19.95万 - 项目类别:
Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
女性研究和指导计划中独特的心血管危险因素
- 批准号:
8033082 - 财政年份:2010
- 资助金额:
$ 19.95万 - 项目类别:
Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
女性研究和指导计划中独特的心血管危险因素
- 批准号:
8610940 - 财政年份:2010
- 资助金额:
$ 19.95万 - 项目类别:
FEMALE GENDER AND ITS INFLUENCE ON GENETIC EXPRESSION OF RISK GENES
女性性别及其对风险基因基因表达的影响
- 批准号:
7379265 - 财政年份:2006
- 资助金额:
$ 19.95万 - 项目类别:
DIETARY SALT INTAKE AND VASCULAR FUNCTION IN HEALTHY MEN
健康男性的膳食盐摄入量和血管功能
- 批准号:
7379284 - 财政年份:2006
- 资助金额:
$ 19.95万 - 项目类别:
Female gender & expression of risk genes in hypertension
性别 女性
- 批准号:
7010658 - 财政年份:2005
- 资助金额:
$ 19.95万 - 项目类别:
FEMALE GENDER AND ITS INFLUENCE ON GENETIC EXPRESSION OF RISK GENES
女性性别及其对风险基因基因表达的影响
- 批准号:
7204547 - 财政年份:2005
- 资助金额:
$ 19.95万 - 项目类别:
Blood Pressure in Postmenopausal Women: A GCRC Study
绝经后妇女的血压:GCRC 研究
- 批准号:
6889612 - 财政年份:2003
- 资助金额:
$ 19.95万 - 项目类别:
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