A Chiang Mai University - HMRI MRI/MRS Project: A Neurobiology Study of Methamphe

描述（由申请人提供）：由于泰国清迈大学放射技术系新安装的1.5 T Philips MR扫描仪具有最先进的MR技术，并且为了推进和扩展MR技术的本地专业知识，本提案得以实现。在临床研究环境中缺乏MRI和MRS方法的当地知识被证明是目前当地对艾滋病毒/艾滋病和药物滥用临床研究兴趣的主要障碍。这项建议的第一个目的是建立适合长期临床研究的MR技术的本地专业知识。将加强对泰国北方当地MR物理学家、医疗保健专业人员和技术人员的培训和指导，并为在这种资源有限的环境中继续发展学术放射学提供支持。本提案中选择的临床研究课题利用了清迈大学RIHES单位目前积极开展的艾滋病毒/艾滋病和药物滥用流行病学调查临床研究。它缺乏艾滋病毒感染和药物滥用对中枢神经系统影响的神经生物学方面的专门知识。这项建议将填补这一空白。将收集沿着少量HIV感染者、甲基苯丙胺滥用者和合并症受试者的规范性脑部MRI和MRS数据。这些数据将作为后续R 01资助申请的CNS功能障碍假说的初步数据。

DESCRIPTION (provided by applicant): Due to the availability of state-of-the-art MR technology with its newly installed 1.5T Philips MR scanner at the Department of Radiological Technology, Chiang Mai University, Thailand and with the purposes of advancing and expanding local expertise in MR technology this proposal has been made possible. The lack of local knowledge on MRI and MRS methods in clinical research setting is proving to be a major barrier for the current local interest in clinical research in HIV/AIDS and drug abuse. The first aim of this proposal is to build local expertise in MR technology suitable for long term clinical research. Training and mentoring of local MR physicists, healthcare professionals and technicians in Northern Thailand will be enhanced and support provided for the continued development of academic radiology in this resource limited setting. The clinical research topics chosen in this proposal take advantage of the current active clinical research in epidemiological investigations in HIV/AIDS and drug abuse at the RIHES unit of Chiang Mai University. It lacks expertise in neurobiology of the effect of HIV infection and drug abuse on the central nervous system (CNS). This proposal will fill that gap. Normative brain MRI and MRS data will be collected along with a small number of subjects who are HIV infected, methamphetamine abusers, and subjects with co- morbidities. These data will serve as preliminary data to develop hypothesis in the dysfunction of CNS for subsequence R01 grant application.