A Multi-Scale Finite Element Musculoskeletal Modeling Framework Applied to Curren

描述(申请人提供)：本提案的目标是创建一个多尺度的人体有限元(FE)模型，将动态肌肉建模和结构有限元分析结合到一个框架中，通过与体外和体内数据的比较在多个尺度上验证该模型，并将该建模框架应用于日常生活活动中自然和TKR植入的膝关节的特定对象分析。FE框架允许对组织进行可互换的刚性和可变形表示，从而能够评估肌肉、韧带和软骨结构中的应力和应变。目前肌肉骨骼系统的计算模型没有将肌肉骨骼系统的多尺度复杂性、跨越关节的许多肌肉的力和冗余度以及组织的变形性合并到一个单一的框架中。部分由于这些限制，计算机模型和模拟在骨科和肌肉骨骼研究中没有被广泛应用。这项提案的具体目标将解决这些限制，并通过开辟一条更真实地表示人体组织的新途径，加速人体建模和模拟方面的创新。首次在单一的多尺度可变形建模框架内通过优化来预测测试对象的肌力。值得注意的是，对传递到组织的力、应力和应变的准确了解跨越了许多范围和学科。这一开创性的举措将帮助工程师、临床医生和研究人员创建和改进手术程序、康复方案、假肢和植入物的设计，并提高对损伤和疾病的理解。

DESCRIPTION (provided by applicant): The objectives of this proposal are to create a multi-scale, finite element (FE) model of the human body that combines dynamic muscle modeling and structural FE analysis into a single framework, to validate the model at multiple scales by comparison to in vitro and in vivo data, and to apply the modeling framework to subject- specific analyses of the natural and TKR implanted knee during activities of daily living. The FE framework allows for interchangeable rigid and deformable representations of the tissues, which enables stress and strain evaluation in muscle, ligament and cartilage structures. Current computational models of the musculoskeletal system do not incorporate into a single framework the multi-scale complexity of the musculoskeletal system, the force and redundancy of the many muscles spanning the joints, and the deformability of the tissues. Due in part to these limitations, computer models and simulations are not widely applied in orthopedics and musculoskeletal research. The specific aims of this proposal will address these limitations and accelerate innovation in human modeling and simulation by opening a new path for more realistic representation of human tissue. For the first time, muscle forces for test subjects will e predicted by optimization within a single multi-scale deformable modeling framework. Significantly, accurate knowledge of the forces, stresses and strains transmitted to the tissues cuts across many scales and disciplines. This ground-breaking initiative will help engineers, clinicians, and researchers to create and improve the design of surgical procedures, rehabilitation protocols, prosthetics and implants, and improve understanding of injury and disease.