A Multi-Scale Finite Element Musculoskeletal Modeling Framework Applied to Curren

描述（由申请人提供）：本提案的目标是创建一个多尺度的人体有限元（FE）模型，将动态肌肉建模和结构FE分析结合到一个框架中，通过与体外和体内数据的比较，在多个尺度上验证模型，并将建模框架应用于日常生活活动中天然膝关节和TKR植入膝关节的受试者特定分析。FE框架允许组织的可互换刚性和可变形表示，这使得肌肉，韧带和软骨结构的应力和应变评估成为可能。目前的肌肉骨骼系统计算模型没有将肌肉骨骼系统的多尺度复杂性、跨越关节的许多肌肉的力和冗余以及组织的可变形性纳入一个单一的框架。部分由于这些限制，计算机模型和模拟并没有广泛应用于骨科和肌肉骨骼研究。本提案的具体目标将解决这些限制，并通过开辟更真实的人体组织表示的新途径，加速人体建模和仿真的创新。第一次，测试对象的肌肉力将在一个单一的多尺度可变形建模框架内通过优化来预测。值得注意的是，传递到组织的力、应力和应变的准确知识跨越了许多尺度和学科。这项开创性的倡议将帮助工程师、临床医生和研究人员创造和改进外科手术程序、康复方案、假肢和植入物的设计，并提高对损伤和疾病的理解。

DESCRIPTION (provided by applicant): The objectives of this proposal are to create a multi-scale, finite element (FE) model of the human body that combines dynamic muscle modeling and structural FE analysis into a single framework, to validate the model at multiple scales by comparison to in vitro and in vivo data, and to apply the modeling framework to subject- specific analyses of the natural and TKR implanted knee during activities of daily living. The FE framework allows for interchangeable rigid and deformable representations of the tissues, which enables stress and strain evaluation in muscle, ligament and cartilage structures. Current computational models of the musculoskeletal system do not incorporate into a single framework the multi-scale complexity of the musculoskeletal system, the force and redundancy of the many muscles spanning the joints, and the deformability of the tissues. Due in part to these limitations, computer models and simulations are not widely applied in orthopedics and musculoskeletal research. The specific aims of this proposal will address these limitations and accelerate innovation in human modeling and simulation by opening a new path for more realistic representation of human tissue. For the first time, muscle forces for test subjects will e predicted by optimization within a single multi-scale deformable modeling framework. Significantly, accurate knowledge of the forces, stresses and strains transmitted to the tissues cuts across many scales and disciplines. This ground-breaking initiative will help engineers, clinicians, and researchers to create and improve the design of surgical procedures, rehabilitation protocols, prosthetics and implants, and improve understanding of injury and disease.