Core A: Administrative Core

核心A的目的是协调该项目的行政职能，并营造一种高度沟通、协作和热情的氛围，以促进该应用程序中提出的科学。Hanein博士作为核心项目负责人，将负责该项目的整体管理和监督。Hanein博士将由SBIMR提供的行政助理Debbie Signer女士协助，她将担任该计划项目的管理员。核心A将作为各机构（SBIMR， UCSD， UVA和Harvard）， 7名调查员和所有其他相关人员以及NIGMS之间的联系接口。六名以太项目负责人和共同研究人员将通过SBMRI颁发的分包合同获得资金，每位项目负责人和共同研究人员将负责资金的日常管理和研究的科学监督。所有的Pis都是非常积极的，成功的科学家，所以预期不需要高水平的监督。然而，为了跟踪进展，更重要的是，为了分享新的成果并提供建议，所有的Pis将在每月的电话会议上提交简短的进展报告。根据这些报告和讨论，如果有任何问题与生产力或管理问题。在与指导委员会协商后，Hanein博士将与任何遇到问题的实验室密切合作，使事情回到正确的轨道上。再一次，考虑到科学经验和个人的生产力，这是极不可能的。核心A将协调所有合作会议，组织项目和核心的定期会议和评审（每年至少一次），与科学顾问委员会（SAB）保持联系，与科学顾问委员会（SAB）组织年度科学静修，并促进初级科学家的培训。除了这些职责外，行政核心还将监督项目的预算管理，协助准备出版物，并维护项目网站。

The purpose of Core A is to coordinate the administrative function of the Program Project and to foster a highly communicative, collaborative, and enthusiastic atmosphere to promote the science proposed in this application. Dr, Hanein, the PI of the core, will be responsible for the overall administration and supervision of this Program Project. Dr. Hanein will be assisted by an administrative assistant, Ms. Debbie Signer, provided by SBIMR, who will serve as the Administrator for the Program Project. Core A will serve as the interface of contact between the institutions (SBIMR, UCSD, UVA and Harvard), the 7 investigators, and all other personnel involved, as well as with the NIGMS. The six ether project leaders and co-investigators will receive funding via subcontracts issued by SBMRI, and each project leader and co-lnvestigator will be responsible for the day to day administration of the funds and the scientific oversight of the research. All Pis are highly motivated, successful scientists, so there is no anticipated need for a high level ef supervision. However, to track progress and, more importantly, to share new results and provide advice, all Pis will submit brief progress reports at monthly conference calls. Based on these reports and discussions, if there is any problem with productivity or management issues. Dr. Hanein, in consultation with the steering committee will work closely with any lab experiencing problems to put things back on the right track. Again, given the scientific experience and productivity of the individuals, this is highly unlikely. Core A will provide all coordination of collaborative meetings, organize regular meetings and reviews of the projects and cores (at least once a year), maintain contact with the Scientific Advisory Beard (SAB), organize the annual scientific retreat with the SAB and facilitate training of junior scientists. In addition to these responsibilities, the administrative core will oversee budget management for the Program Project, assist in the preparation of publications, and maintain the Program Project's website.