Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)

描述(由申请人提供)：这项建议是为K23指导的以患者为导向的研究职业发展奖，该奖项将为候选人在翻译神经认知研究领域的成功独立职业生涯做好准备。这位候选人和他在德克萨斯大学西南医学中心(UTSW)和哥伦比亚大学/纽约州立大学(CU/NYSPI)的导师们设计了一条阶段性的指导和安排过渡(SMART)职业发展道路，使他能够成为一名熟练的独立研究员，从事神经认知功能、情绪障碍和神经刺激干预方面的工作。这一独特的研究利基将使候选人能够利用他的导师的专业知识，同时确立他作为独立调查员的个人身份。智能路径形成了一个由专家导师和顾问(穆斯塔法·M·侯赛因博士、莎拉·H·利桑比博士、C.Munro Cullum博士、Herb Terrace博士、Ira Bernstein博士、George Alexopoulos博士和Harold A.Pincus博士)组成的协作网络。职业发展计划包括学术教学和研讨会、专家指导、在UTSW和CU/NYSPI的实践经验以及有形的生产力，包括同行评审的手稿和拨款申请。候选人的职业生涯独一无二的是，在本奖项期间，初选职位从UTSW到CU/NYSPI的预先计划转变。这将促进他的过渡目标，并使他顺利过渡到独立地位。他的研究项目的目标是开发和进行翻译研究评估神经认知记忆过程(TREC-MP)。使用模型动物研究神经认知功能在基础科学方法论中得到了广泛的应用。然而，由此产生的临床人类使用的应用一直受到限制。TREC-MP是一个翻译项目，旨在检查为接受电惊厥和磁惊厥治疗的非人类灵长类动物开发的实验性计算机化神经认知测量方法在人类中的心理测量特性。这项渐进式研究旨在优化健康人群的实验神经认知电池，然后确定抑郁症对测试成绩的影响，最后确定接受电惊厥治疗(ECT)的抑郁症受试者的神经认知成绩。ECT的认知影响是公认的，并且具有相当大的临床意义，但人们不太了解的是抑郁症和ECT之间复杂的相互作用对认知成分过程的影响。因此，需要更新的认知评估方法来阐明相似和不同物种之间的认知过程，并确定接受ECT治疗的患者记忆障碍的潜在认知成分过程。正如最近的NIMH翻译神经认知研究和临床倡议所表明的那样，一个有用的策略是为特定的神经认知领域和组成过程开发比较的非人类灵长类和人类神经认知测量。基于基础科学对非人类灵长类动物的神经认知研究，应用特定的神经认知电池为理解记忆缺陷的认知成分过程提供了一种强有力的方法，从而使未来有针对性的治疗干预和有用的临床神经认知措施的发展成为可能。[该项目的目的是：1)开发和验证用于健康人类参与者的实验性神经认知测量方法；2)确定抑郁症对实验神经认知测量结果的影响；以及3)确定ECT对实验神经认知测量结果的影响。]分析将采用经典测验和项目反应理论的统计方法。这个项目具有科学创新性和重要性，因为它将为应试者提供一个平台，进行转化性神经认知研究，帮助他了解记忆障碍的病因，并最终设计适当的临床神经认知措施和干预措施。候选人的智能路径和TREC-MP项目为他作为一名独立的翻译神经认知科学家的个性化和系统性发展奠定了基础。

DESCRIPTION (provided by applicant): This proposal is for a K23 Mentored Patient Oriented Research Career Development Award that will prepare the candidate for a successful independent career in translational neurocognitive research. The candidate and his mentors at UT Southwestern Medical Center (UTSW) and Columbia University/New York State Psychiatric Institute (CU/NYSPI) designed a Staged Mentored and Arranged Transition (SMART) career development pathway to enable him to become a proficient, independent investigator working at the intersection of neurocognitive function, mood disorders, and neurostimulation interventions. This unique research niche will allow the candidate to leverage the expertise of his preceptors while establishing his individual identity as an independent investigator. The SMART pathway forms a collaborative network of expert mentors and advisors (Drs. Mustafa M. Husain, Sarah H. Lisanby, C. Munro Cullum, Herb Terrace, Ira Bernstein, George Alexopoulos, and Harold A. Pincus). The career development plan is comprised of scholarly didactics and seminars, expert preceptorship, hands-on experience at UTSW and CU/NYSPI, as well as tangible productivity including peer-reviewed manuscripts and grant applications. Unique to the candidate's career path is the pre- planned shift in primary appointment from UTSW to CU/NYSPI during this award period. This will facilitate his transitional goals as well as smooth his transition to independent status. The goal of his research project is to develop and conduct Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP). The use of model animals to study neurocognitive functions has been employed extensively in basic science methodologies. However, the resulting applications for clinical human use have been limited. TREC-MP is a translational project that examines the psychometric properties in humans of experimental computerized neurocognitive measures developed for nonhuman primates undergoing electroconvulsive shock and magnetic seizure therapy. This incremental research study is designed to optimize the experimental neurocognitive battery in a healthy human cohort, then to determine the effects of depression on test performance, and finally to determine the neurocognitive performance of depressed subjects undergoing electroconvulsive therapy (ECT). The cognitive impact of ECT is well recognized and of considerable clinical significance, but what is less well understood is the complex interaction between depression and ECT on cognitive component processes. As such, newer methods of cognitive assessment are needed to elucidate similar and divergent cognitive processes across species, and identify underlying cognitive component processes of memory impairment in patients receiving ECT. As exemplified in recent NIMH translational neurocognitive research and clinical initiatives, one useful strategy would be the development of comparative nonhuman primate and human neurocognitive measures for specific neurocognitive domains and component processes. The application of a specific neurocognitive battery, predicated on basic science neurocognitive research with nonhuman primates provides a powerful method for understanding the cognitive component processes of memory deficits, thereby permitting the future development of targeted treatment interventions and useful clinical neurocognitive measures. [The aims of this project are: 1) Develop and validate experimental neurocognitive measures for use with healthy human participants, 2) Determine effects of depression on performance on experimental neurocognitive measures, and 3) Determine effects of ECT on performance on experimental neurocognitive measures.] Analyses will be conducted with both classical test and item response theory statistics. This project is scientifically innovative and important because it will provide a platform for the candidate to conduct translational neurocognitive research to help him understand the etiology of memory impairment and ultimately design appropriate clinical neurocognitive measures and interventions. The candidate's SMART pathway and TREC-MP project set the stage for his individualized and systematic development as an independent translational neurocognitive scientist.