Antiviral Drugs for Arenaviruses

描述（由申请人提供）：这里描述的项目目标是开发一种抗病毒药物，用于治疗和预防拉沙热和其他沙粒病毒源性出血热。先前的文库筛选确定了几种很好的候选拉沙病毒进入小分子抑制剂。随后的体外和体内鉴定鉴定出ST-193系列，对5种不同的a类出血热沙粒病毒具有广谱活性。该系列在豚鼠和食蟹猴两种拉沙热动物模型中显示出保护作用。该申请的具体目标是优化该化学系列，以确定临床前开发的合适候选药物，并收集必要的数据，以支持提交研究新药（IND）申请。

DESCRIPTION (provided by applicant): The goal of the program described here is to develop an antiviral drug for treating and preventing Lassa fever and other hemorrhagic fevers of arenavirus origin. Previous library screening identified several good candidate small molecule inhibitors of Lassa virus entry. Subsequent in vitro and in vivo characterization identified a potent series, ST-193, with broad- spectrum activity against 5 distinct Category A hemorrhagic fever Arenaviruses. This series has shown protective efficacy in two animal models of Lassa fever, guinea pigs and cynomolgus monkeys. The specific objective of this application is to optimize this chemical series to identify an appropriate candidate for preclinical development and to collect the necessary data to support the submission of an application for an Investigational New Drug (IND).