The Neural Basis of Apathy in Frontotemporal Degeneration: A Longitudinal Study

额颞叶退化中冷漠的神经基础：一项纵向研究

• 批准号: 8647992
• 负责人: Lauren M Massimo
• 金额: $ 4.98万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647992
• 关键词: Activities of Daily Living; Advanced Practice Nurse; Affect; Alleles; Anatomic structures; Anisotropy; Anterior; Apolipoprotein E; Atrophic; Bathing; Behavior; Behavioral; Biological; Biological Factors; Brain; Brain Pathology; Brain region; Caregiver Burden; Caregivers; Caring; Clinical; Cognitive; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Education; Effectiveness of Interventions; Environmental Risk Factor; Family Caregiver; Fellowship; Financial compensation; Frontotemporal Dementia; Functional disorder; Funding; Genetic; Genetic Databases; Geriatric Nursing; Goals; Grant; Haplotypes; Health; Imaging Techniques; Impairment; Individual; Individual National Research Service Award; Interdisciplinary Study; Intervention; Investigation; Knowledge; Laboratory Study; Lead; Leisure Activities; Longitudinal Studies; Measures; Mediating; Methods; Morbidity - disease rate; Motivation; National Institute of Nursing Research; National Research Service Awards; Natural History; Neurodegenerative Disorders; Neurological Nursing; Neurologist; Nurses; Nursing Research; Occupational; Occupations; Outcome; Participant; Patients; Performance at work; Persons; Play; Predoctoral Individual National Research Service Award; Prefrontal Cortex; Research; Research Personnel; Research Priority; Research Proposals; Research Training; Resources; Risk; Role; Scientist; Sterile coverings; Strategic Planning; Syndrome; Testing; Time; Training; Variant; Work; base; brain behavior; career; cingulate cortex; cognitive reserve; cost; design; early onset; effective intervention; experience; gray matter; improved; innovation; insight; longitudinal analysis; longitudinal course; mortality; neuroimaging; neuropsychiatry; neuropsychological; post-doctoral training; programs; public health relevance; relating to nervous system; skills; tau Proteins; theories; therapy development; white matter; white matter change

Project Summary The purpose of this individual National Research Service Award (NRSA) is to provide postdoctoral research training for a neuroscience nurse to become an independent investigator focusing on the behavioral and biological mechanisms that contribute to neuropsychiatric syndromes such as apathy in patients with neurodegenerative disease (ND). In addition to coursework and the acquisition of new research skills, I propose to focus this NRSA on impairments of goal-directed behavior (GDB) that are very common but understudied in ND. The syndrome of apathy, defined as a reduction in self-generated or voluntary behavior,1 has profound consequences for morbidity and mortality in the patient and for family caregiver burden. Treatments for apathy are hindered because of our poor understanding of the mechanisms underlying this behavior. In my cross-sectional dissertation data (funded by NINR F31NR013306), I identified three subtypes of apathy in patients with behavioral variant Frontotemporal Degeneration (bvFTD): difficulty with initiation, planning or motivation. Each subtype is related to disease in distinct frontal regions. Based on preliminary longitudinal data, I will collect additional data to test the hypothesis that subtypes of apathy will worsen over time, and that decline will be restricted to the subtype of initial impairment. I will also extend my research program to investigate how biologic and environmental factors contribute to worsening in apathy. I have had more than 8 years of experience as an Advanced Practice Nurse and Research Nurse Coordinator in a nationally ranked laboratory that studies the neural basis for behavior in ND. I have direct access to research participants as well as a large database of genetic and neuroimaging data that I will incorporate into my analyses. My research training will be guided by two internationally known scientists, Dr. Ann Kolanowski, a well-known gerontological nurse expert and leader, and Dr. Murray Grossman, a highly acclaimed cognitive neurologist and experienced scientist. The interdisciplinary training during the performance of this work will serve as an essential component in attaining my career goal to become an independent neuroscience nurse researcher. The long-term impact of this research training will be profound for patients with ND, their caregivers, and families. Knowledge of the natural history of apathy is essential in the development of interventions for subtypes of apathy. Consistent with the National Institute of Nursing Research (NINR) priorities, this innovative work will lead to a better understanding of these brain behavior relationships and with this new knowledge, tailored interventions will be designed to reduce apathy and the poor health outcomes that are associated with this devastating condition.

项目摘要 这个个人国家研究服务奖（NRSA）的目的是提供博士后研究 培训神经科学护士成为一名独立的调查员，专注于行为和 导致神经精神综合征的生物学机制，例如 神经退行性疾病（ND）。除了课程和获得新的研究技能，我 我建议把这个NRSA集中在目标导向行为（GDB）的损伤上，这些损伤非常常见，但 在ND学习。冷漠综合征，定义为自我产生或自愿行为的减少， 对患者的发病率和死亡率以及家庭照顾者的负担产生深远的影响。 冷漠症的治疗受到阻碍，因为我们对这背后的机制缺乏了解。 行为在我的横截面论文数据（由NINR F31NR013306资助）中，我确定了三种亚型 行为变异性额颞叶变性（bvFTD）患者的情感淡漠：启动困难， 计划或动机。每个亚型都与不同额叶区域的疾病有关。 基于初步的纵向数据，我将收集更多的数据来检验这一假设， 冷漠会随着时间的推移而恶化，并且这种下降将仅限于初始损害的亚型。我也会 扩展我的研究计划，以调查生物和环境因素如何导致恶化， 冷漠我有超过8年的经验，作为一个先进的实践护士和研究护士 协调员在一个国家级的实验室，研究神经基础的行为在ND。我有直接 访问研究参与者以及遗传和神经成像数据的大型数据库，我将 纳入我的分析中。我的研究培训将由两位国际知名科学家指导， 安Kolanowski，著名的老年护理专家和领导者，和默里格罗斯曼博士，一个高度 著名的认知神经学家和经验丰富的科学家。 在开展这项工作期间进行的跨学科培训将是 实现我的职业目标，成为一名独立的神经科学护士研究员。的长期影响 这项研究培训将对ND患者、他们的护理人员和家庭产生深远的影响。知识 冷漠的自然史对于制定针对冷漠亚型的干预措施至关重要。一致 随着国家护理研究所（NINR）的优先事项，这项创新工作将导致更好的 了解这些大脑行为的关系，并与这些新的知识，量身定制的干预措施将 旨在减少与这种毁灭性疾病相关的冷漠和不良健康结果。