A Multi-Site Trial of a Cognitive Rehabilitation Intervention for Persons with MS
针对多发性硬化症患者的认知康复干预的多中心试验
基本信息
- 批准号:8643370
- 负责人:
- 金额:$ 47.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-27 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingActivities of Daily LivingAddressAffectAttentionAxonBehaviorCellsCentral Nervous System DiseasesClinical Trials DesignCognitionCognitiveCognitive deficitsCompetenceComplexComputer AssistedComputersDiseaseEmotionalFamilyGoalsHealthHome environmentImmune systemImpairmentIndividualInterventionKnowledgeLearningLifeMeasurementMemoryMultiple SclerosisMyelinNIH Program AnnouncementsNeuraxisNeurocognitiveNeuropsychological TestsOutcomeParticipantPerformancePersonsProblem SolvingQuality of lifeRandomizedRandomized Controlled TrialsResearchResearch PersonnelSamplingScanningSelf EfficacySiteSocietiesSymptomsTestingTrainingTranslatingUnited StatesWorkbasecognitive changecognitive functioncognitive rehabilitationcomparison groupdesigneffective interventionexperiencefollow-upgroup interventionimprovedinformation processinginnovationinstrumental activity of daily livingintervention effectmulti-site trialneuropsychologicalnovelpost interventionprocessing speedpublic health relevanceresponseskillssocialstatisticstreatment as usual
项目摘要
PROJECT SUMMARY / ABSTRACT
The effects of multiple sclerosis (MS) on cognition, thought to occur in 50-75% of persons with MS, have
gained increasing recognition as one of the major disabling symptoms of the disease. While numerous studies
have addressed the emotional and physical impact of MS, little attention has been given to strategies that
might help manage the cognitive changes commonly experienced by persons with MS. The proposed study will
test a novel computer-assisted cognitive rehabilitation intervention, MAPSS-MS (Memory, Attention, & Problem
Solving Skills for Persons with MS). The MAPSS-MS integrates the powerful effects of group interventions to
build self-efficacy for new cognitive compensatory strategies/behaviors with individual home-based computer-
assisted practice of cognitive skills. The computer training will assist individuals to develop cognitive skills that
they can apply to everyday life using the compensatory strategies learned in the class sessions. In our recently
completed exploratory study with 61 persons with MS (R21NR011076), the eight-week MAPSS-MS
intervention was acceptable and feasible and had medium to large effects on the use of compensatory
strategies and performance on neuropsychological tests of verbal memory. The proposed study will test the
refined MAPSS-MS intervention with a larger more diverse sample (N=180) across multiple sites, extend the
period of post-intervention follow-up to 6 months and establish whether performance improvements on
neuropsychological tests make the important transfer to improved neuro-cognitive functioning in everyday life.
The specific aims of this study are to: (1) Evaluate the efficacy of the MAPSS-MS cognitive rehabilitation
intervention in improving overall neuro-cognitive competence of persons with MS in activities of daily living,
including verbal memory performance, use of compensatory cognitive strategies, and performance on
cognitive-related instrumental activities of daily living (IADL); (2) Evaluate the efficacy of the MAPSS-MS
intervention in improving self-efficacy and related aspects of cognitive performance (non-verbal
learning/memory, information processing speed and attention, verbal fluency and complex scanning and
tracking) among persons with MS; and (3) Determine the number of intervention participants who achieve and
maintain their self-identified cognitive goals at three and six months following the intervention. The effects of
the intervention on outcome variables will be assessed using a randomized controlled trial design with a
comparison group receiving usual care computer games. Measurements of study variables will occur at
baseline, immediately after the MAPSS-MS intervention, and three months and six months after the
intervention is complete. Statistical analysis will include descriptive statistics and HLM analysis to account for
the nested design. The intent-to-treat approach will be used.
项目摘要/摘要
多发性硬化症对认知的影响被认为发生在50%-75%的多发性硬化症患者中,
越来越多的人认识到这是该病的主要致残性症状之一。虽然众多的研究
已经解决了多发性硬化症对情绪和身体的影响,但很少有人关注
可能有助于管理多发性硬化症患者通常经历的认知变化。
测试一种新的计算机辅助认知康复干预,MAPSS-MS(记忆、注意力和问题
多发性硬化症患者的解决技能)。MAPSS-MS整合了团体干预的强大效果
使用个人家用计算机为新的认知补偿策略/行为建立自我效能-
认知技能的辅助练习。计算机培训将帮助个人发展认知技能,
他们可以使用在课堂上学到的补偿策略应用到日常生活中。在我们最近
完成了对61名MS患者(R21NR011076)的探索性研究,MAPSS-MS为期8周
干预是可以接受和可行的,并对补偿性措施的使用产生了中等到很大的影响
言语记忆神经心理测试的策略和表现。拟议的研究将测试
通过跨多个站点的更大、更多样化的样本(N=180)进行改进的MAPSS-MS干预,扩展
干预后6个月的随访期,并确定是否在
神经心理测试对改善日常生活中的神经认知功能具有重要作用。
本研究的具体目的是:(1)评价MAPSS-MS认知康复的疗效
日常生活活动中改善多发性硬化症患者整体神经认知能力的干预
包括言语记忆表现,补偿性认知策略的使用,以及
认知相关日常生活活动量表(IADL);(2)评估MAPSS-MS的疗效
提高自我效能感和认知表现的相关方面的干预(非语言
学习/记忆,信息处理速度和注意力,语言流利性和复杂的扫描和
跟踪)多发性硬化症患者;以及(3)确定达到和
在干预后的三个月和六个月维持他们自己确定的认知目标。的影响
对结果变量的干预将使用随机对照试验设计进行评估,
对照组接受常规护理电脑游戏。研究变量的测量将在
基线,在MAPSS-MS干预后立即,以及在MAPSS-MS干预后三个月和六个月
干预已经完成。统计分析将包括描述性统计和HLM分析,以说明
嵌套设计。将使用意向治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HEATHER A BECKER的其他文献
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{{ truncateString('HEATHER A BECKER', 18)}}的其他基金
A Multi-Site Trial of a Cognitive Rehabilitation Intervention for Persons with MS
针对多发性硬化症患者的认知康复干预的多中心试验
- 批准号:
8744642 - 财政年份:2013
- 资助金额:
$ 47.16万 - 项目类别:
A Multi-Site Trial of a Cognitive Rehabilitation Intervention for Persons with MS
针对多发性硬化症患者的认知康复干预的多中心试验
- 批准号:
9079273 - 财政年份:2013
- 资助金额:
$ 47.16万 - 项目类别:
Promoting the Health of Cancer Survivors with Pre-Existing Functional Limitations
促进已有功能限制的癌症幸存者的健康
- 批准号:
7760115 - 财政年份:2009
- 资助金额:
$ 47.16万 - 项目类别:
Promoting the Health of Cancer Survivors with Pre-Existing Functional Limitations
促进已有功能限制的癌症幸存者的健康
- 批准号:
7578607 - 财政年份:2009
- 资助金额:
$ 47.16万 - 项目类别:
HRT Decision Support for Women with Mobility Impairment
为行动不便的女性提供 HRT 决策支持
- 批准号:
6664779 - 财政年份:2003
- 资助金额:
$ 47.16万 - 项目类别:
Hormone replacement therapy amony women with disabilities
残疾妇女接受激素替代疗法
- 批准号:
6595960 - 财政年份:2002
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$ 47.16万 - 项目类别:
Hormone replacement therapy amony women with disabilities
残疾妇女接受激素替代疗法
- 批准号:
6453652 - 财政年份:2001
- 资助金额:
$ 47.16万 - 项目类别:
Hormone replacement therapy amony women with disabilities
残疾妇女接受激素替代疗法
- 批准号:
6565170 - 财政年份:2001
- 资助金额:
$ 47.16万 - 项目类别:
Hormone replacement therapy amony women with disabilities
残疾妇女接受激素替代疗法
- 批准号:
6452318 - 财政年份:2001
- 资助金额:
$ 47.16万 - 项目类别:
Hormone replacement therapy amony women with disabilities
残疾妇女接受激素替代疗法
- 批准号:
6302682 - 财政年份:2000
- 资助金额:
$ 47.16万 - 项目类别:
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