ACS-TR19 CYCLOTRON

描述(由申请人提供)：此修订申请申请资金购买由先进回旋加速器系统制造的TR19双粒子回旋加速器，这是支持华盛顿大学当前和未来研究增长所必需的。TR19内的功能组合是支持多种PET放射性核素和放射性药物的最佳选择，这些PET放射性核素和放射性药物是我们NIH资助的研究所需的。TR19是唯一适合生产包括铜-、锆-、I-124在内的广谱正电子发射同位素的机器；它也是增加C-11等“标准”放射性核素生产的理想设备， F-18，临床影像研究所需的O-15。TR19将安装在华盛顿大学放射科(吴)。吴在这个地点附近有正在进行的住院和门诊研究，提供独特的临床和合作研究项目。TR19将提供一个更可靠、更灵活的平台，将我们的回旋加速器设施的放射性同位素生产能力提高一倍，从而实现提高我们支持华盛顿大学当前和未来研究增长的能力的长期目标。通过显著提高我们生产放射性同位素的可靠性，PET研究可以继续进行，而不会担心由于频繁和严重的维护问题而导致不可避免的市中心和研究研究取消的并发症。与目前的CS-15和JSW168回旋加速器不同，TR19将提高非标准同位素生产的效率和灵活性，并改善标准PET放射性核素的生产能力。

DESCRIPTION (provided by applicant): This revised application requests funds to purchase a TR19 dual particle cyclotron manufactured by Advance Cyclotron Systems which is necessary to support ongoing and future research growth at Washington University. The combination of features within the TR19 is optimal for supporting the diverse number of PET radionuclides and radiopharmaceuticals needed to support our NIH-funded research. The TR19 which is the only machine suitable to produce a broad spectrum of positron-emitting isotopes including Cu-64, Zr-89, I-124; it is also ideal for increasing the production of "standard" radionuclides such as C-11, F-18, an O-15 required for our clinical imaging studies. The TR19 will be installed in the Department of Radiology at Washington University (WU). WU has ongoing inpatient and outpatient research near this location that offers unique clinical and collaborative research projects. The TR19 will fulfill the long-term objective to increase our ability to support ongoing and future research growth at Washington University by providing a more reliable and flexible platform that will double the radioisotope production capacity of our cyclotron facility. By significantly enhancing our reliability to produce radioisotopes, PET research can continue without concern of complications due to frequent and severe maintenance issues leading to unavoidable downtown and the cancellation of research studies. Unlike the current CS-15 and JSW168 cyclotrons, the TR19 will allow increased efficiency and flexibility for non-standard isotope production as well as improved production capabilities of the standard PET radionuclides.