HPV-related neoplasia among HIV-seropositive Indian men who have sex with men

印度 HIV 血清阳性男男性行为者中 HPV 相关肿瘤

• 批准号: 8336816
• 负责人: JOEL Michael PALEFSKY
• 金额: $ 15.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8336816
• 关键词: AIDS Malignancy Consortium; Anal Intraepithelial Neoplasia; Anal canal; Anatomic Sites; Anogenital Human Papilloma Virus Infection; Anus; Biopsy; Blood; Cancerous; Caring; Cervical Intraepithelial Neoplasia; Cervix Uteri; Cohort Studies; Collaborations; Cross-Sectional Studies; Cytology; DNA; Data; Detection; Developed Countries; Development; Diagnosis; Disease; Enrollment; Female; Future; General Population; HIV; High Prevalence; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Incidence; Incidence Study; India; Individual; Infection; Joints; Knowledge; Lead; Learning; Lesion; Life; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Neoplasms; Oncogenic; Oral; Population; Premalignant; Prevalence; Prevalence Study; Questionnaires; Recruitment Activity; Research; Resolution; Risk Factors; Sampling; Sexual Partners; Site; Staging; Testing; Training; Trust; United States; Viral Load result; Visit; Vulnerable Populations; Woman; antiretroviral therapy; base; cancer prevention; high risk; medical schools; men; men who have sex with men; novel vaccines; penis; programs; prospective; quality assurance; sex

DESCRIPTION (provided by applicant): Men who have sex with men (MSM) constitute a substantial proportion of the Indian HIV-seropositive population. The incidence of human papillomavirus (HPV)-related malignancies and their precursor lesions is increased in HIV-seropositive MSM including cancers of the anus and penis. We recently completed a cross-sectional study of HPV infection in 300 HIV-seropositive MSM at Humsafar Trust in Mumbai and Christian Medical College (CMC) in Vellore and showed that the prevalence of anogenital HPV infection in this population is very high. However, little is known of the incidence of anogenital HPV- associated disease in this population. We now propose to extend our cross-sectional analysis to study the incidence of anogenital HPV infection and HPV-associated disease in 246 Indian HIV-seropositive MSM. Our specific aims are: 1) Determine the prevalence and incidence of HPV-associated premalignant lesions in the anus and penis in Indian HIV-seropositive men MSM; 2) Describe risk factors for prevalent premalignant lesions in the anus and penis in Indian HIV-seropositive MSM; and 3) Describe the incidence of penile and anal HPV infection in Indian HIV-seropositive MSM. Men will be followed over one year at 6-month intervals for a total of 3 visits. At each visit 123 HIV-seropositive men at each site will be administered a questionnaire. HPV DNA samples will be collected from the anus and penis. Blood will be obtained for CD4+ at all visits and HIV viral load levels at baseline and 12 months. Anal cytology and high resolution anoscopy will be performed with biopsy of visible anal lesions. Penile exams and biopsies will also be performed. HPV DNA testing will be performed at CMC Vellore. Training and quality assurance will be performed at the UCSF. Data from this study will be important for the care of both men and women in India overall, since many Indian MSM have female sexual partners, and HIV-seropositive men may serve as a bridge population to women. Knowledge of HPV-related precancerous disease will be important to planning cancer prevention efforts in HIV-seropositive individuals in India since these HPV-related cancers may be preventable. Data on HPV infection will contribute to the development of optimal next-generation vaccines. This study builds upon a growing collaboration between UCSF, CMC Vellore, Humsafar Trust and the AIDS Malignancy Consortium. It will lead to capacity-building and many additional studies of HPV and associated diseases in India.

描述（由申请人提供）：与男性发生性关系的男性（MSM）占印度HIV阳性人群的很大一部分。在包括肛门和阴茎的癌症（包括肛门和阴茎的癌症）中，人类乳头瘤病毒（HPV）相关的恶性肿瘤及其前体病变的发生率增加。我们最近在Vellore的孟买和基督教医学院（CMC）的Humsafar Trust的300个HIV阳性MSM中完成了一项HPV感染的横断面研究，并表明该人群的肛门生殖器HPV感染的患病率很高。然而，对该人群中肛门生态HPV相关疾病的发生率鲜为人知。现在，我们建议扩展我们的横截面分析，以研究246个印度HIV阳性MSM中肛门生殖器HPV感染和HPV相关疾病的发生率。我们的具体目的是：1）确定印度HIV阳性男性MSM中肛门和阴茎中与HPV相关前病变的患病率和发生率； 2）描述印度HIV阳性MSM中肛门和阴茎中普遍病变的风险因素； 3）描述印度HIV阳性MSM中阴茎和肛门HPV感染的发生率。男性将在一年内以6个月的间隔进行一年的时间，总共3次访问。在每次访问中，每个站点的123名HIV阳性男性都将接受问卷调查。 HPV DNA样品将从肛门和阴茎中收集。在基线和12个月的所有访问和HIV病毒负荷水平下，CD4+将获得血液。肛门细胞学和高分辨率构镜检查将通过可见肛门病变活检进行。阴茎考试和活检也将进行。 HPV DNA测试将在CMC Vellore进行。培训和质量保证将在UCSF进行。这项研究的数据对于整体印度男性和女性的照顾将很重要，因为许多印度MSM都有女性性伴侣，而艾滋病毒阳性男性可能是女性的桥梁人口。对与HPV相关的癌前疾病的了解对于计划在印度艾滋病毒阳性个体的癌症预防工作非常重要，因为这些与HPV相关的癌症可能是可以预防的。 HPV感染的数据将有助于开发最佳的下一代疫苗。这项研究以UCSF，CMC Vellore，Humsafar Trust和AIDS恶性财团之间的越来越多的合作为基础。这将导致印度HPV和相关疾病的许多其他研究。