Novel Dental Resin Composites with Improved Service Life

综述：当前牙科复合修复系统平均使用寿命较短且不断增加 与复合修复体和封闭剂相邻的继发性龋病的发生 开发具有新型单体和聚合物、增强填充物、 和粘合剂组件。这项拟议研究的目标是开发新型牙科复合材料系统， 用于修复体、密封剂和其他在性能和耐久性方面优于 目前使用的BIS-GMA/TEGDMA和氨基甲酸酯-二甲基丙烯酸酯体系。我们将设计和生产新的 不易被酶或水解性降解的单体及其聚合物，建立了一种自身的 愈合技术，显著延长这些复合材料的疲劳寿命，并研制出智能抗菌药物 只有在需要时才在口腔环境中激活的组件。我们提出了三个具体目标 以这三个关键发展为目标。在具体目标1中，我们建议通过替换 含在当前聚合物和键合剂中的可水解酯基团，具有可水解稳定性的乙醚 在相应的聚合物和键合剂中的基团。在具体目标2中，我们将发展自我修复 牙科复合材料(SHDC)将自动修复难以检测和几乎 临床上无法修复。自主自我修复将显著提高这些材料的耐用性 通过防止口腔中遇到的热和机械挑战导致的灾难性故障 环境。在具体目标3中，我们建议通过以下方式建立系统的自卫能力： 纳米粒子具有新型偶联剂的功能，只有在以下情况下才会释放抗菌成分 暴露于细菌攻击或水解性降解。这些新系统的完整性和耐用性将是 与基于BIS-GMA/TEGDMA的商业系统相比，在类似于 口腔环境，包括致龋性生物膜、酶降解、热循环疲劳和 机械性自行车疲劳。我们预计，具有这三种特性的新型材料 具体目标，将大大超过目前基于BIS-GMA-TEGDMA的商业 这些挑战下的材料。因此，可以预见的是，新系统将提供显著的 延长了使用寿命，至少延长了两倍。新系统中的所有功能都可以很容易地集成 由该U01-RFA获奖者开发的其他修复系统，并可用于复合材料 和他们的牙科粘合剂。我们计划通过以下方式共享我们的数据和资源并与获奖者合作 以一切可行的程序实现本方案的目标。

Summary: The short average service life of current dental composite restorative systems and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting dental materials having novel monomers and polymers, reinforcing fillers, and adhesive components. The goal of this proposed research is to develop novel dental composite systems, for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used Bis-GMA/TEGDMA and urethane-dimethacrylate systems. We will design and produce new monomers and their polymers that are not susceptible to enzymatic or hydrolytic degradation, establish a self- healing technique to significantly extend the fatigue life of these composites, and formulate smart antibacterial components which are activated in the oral environment only when needed. We propose three specific aims that target these three key developments. In Specific Aim 1, we propose to improve durability by replacing the hydrolyzable ester groups, contained in current polymers and bonding agents, with hydrolytically stable ether groups in the corresponding polymers and bonding agents. In Specific Aim 2, we will develop self-healing dental composites (SHDC) that will autonomously repair micro-cracks that are hard to detect and almost impossible to repair clinically. Autonomic self-healing will significantly improve the durability of these materials by preventing catastrophic failures caused by thermal and mechanical challenges encountered in the oral environment. In Specific Aim 3, we propose to build a self-defense capability for the systems by incorporating nanoparticles functionalized with novel coupling agents that will release antimicrobial components only when exposed to bacterial attack or hydrolytic degradation. The integrity and durability of these novel systems will be compared with Bis-GMA/TEGDMA based commercial systems under challenges like those that occur in the oral environment, including cariogenic biofilms, enzymatic degradations, thermal cycling fatigue and mechanical cycling fatigue. We expect that the novel materials, having features achieved by these three specific aims, will significantly surpass the performances of current Bis-GMA-TEGDMA-based commercial materials under these challenges. It is thus predictable that the new system will provide a significantly extended service life, at least by a factor of two. All of the features in the new system can be easily integrated into other restorative systems developed by the awardees of this U01-RFA, and can be used in composites and their dental adhesives. We plan to share our data and resources and collaborate with the awardees by way of all feasible procedure to achieve the goals of this program.