Novel Dental Resin Composites with Improved Service Life

具有更长使用寿命的新型牙科树脂复合材料

• 批准号: 8609322
• 负责人: Jirun Sun
• 金额: $ 44.97万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609322
• 关键词: Adhesives; Ammonium; Anti-Bacterial Agents; Binding; Bisphenol A-Glycidyl Methacrylate; Chemical Structure; Chemistry; Composite Dental Resin; Coupling; Data; Dental; Dental Care; Dental Materials; Dental caries; Development; Environment; Esters; Ethers; Failure; Fatigue; Filler; Goals; Healed; Human; Image; Laser Scanning Confocal Microscopy; Life; Life Extension; Mechanics; Methods; Microbial Biofilms; Minimum Inhibitory Concentration measurement; Nutrient; Oral; Performance; Polymers; Procedures; Production; Property; Prunella vulgaris; Research; Resources; Roentgen Rays; Saliva; Scanning Electron Microscopy; Services; Simulate; Solutions; Streptococcus mutans; System; Techniques; Testing; Tooth structure; Urethane; Viscosity; Work; X-Ray Computed Tomography; antimicrobial; base; comparative; composite restoration; dental adhesive; design; healing; improved; monomer; nanoindentation; nanoparticle; nanorod; novel; particle; polymerization shrinkage; prevent; programs; public health relevance; repaired; restoration; restorative composite; triethylene glycol dimethacrylate

Summary: The short average service life of current dental composite restorative systems and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting dental materials having novel monomers and polymers, reinforcing fillers, and adhesive components. The goal of this proposed research is to develop novel dental composite systems, for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used Bis-GMA/TEGDMA and urethane-dimethacrylate systems. We will design and produce new monomers and their polymers that are not susceptible to enzymatic or hydrolytic degradation, establish a self- healing technique to significantly extend the fatigue life of these composites, and formulate smart antibacterial components which are activated in the oral environment only when needed. We propose three specific aims that target these three key developments. In Specific Aim 1, we propose to improve durability by replacing the hydrolyzable ester groups, contained in current polymers and bonding agents, with hydrolytically stable ether groups in the corresponding polymers and bonding agents. In Specific Aim 2, we will develop self-healing dental composites (SHDC) that will autonomously repair micro-cracks that are hard to detect and almost impossible to repair clinically. Autonomic self-healing will significantly improve the durability of these materials by preventing catastrophic failures caused by thermal and mechanical challenges encountered in the oral environment. In Specific Aim 3, we propose to build a self-defense capability for the systems by incorporating nanoparticles functionalized with novel coupling agents that will release antimicrobial components only when exposed to bacterial attack or hydrolytic degradation. The integrity and durability of these novel systems will be compared with Bis-GMA/TEGDMA based commercial systems under challenges like those that occur in the oral environment, including cariogenic biofilms, enzymatic degradations, thermal cycling fatigue and mechanical cycling fatigue. We expect that the novel materials, having features achieved by these three specific aims, will significantly surpass the performances of current Bis-GMA-TEGDMA-based commercial materials under these challenges. It is thus predictable that the new system will provide a significantly extended service life, at least by a factor of two. All of the features in the new system can be easily integrated into other restorative systems developed by the awardees of this U01-RFA, and can be used in composites and their dental adhesives. We plan to share our data and resources and collaborate with the awardees by way of all feasible procedure to achieve the goals of this program.

摘要：目前牙科复合材料修复系统的平均使用寿命较短， 在复合牙釉质和封闭剂附近发生继发性龋， 开发具有新型单体和聚合物，增强填料， 和粘合剂组分。本研究的目标是开发新型牙科复合材料系统， 用于在性能和耐久性方面上级 目前使用的Bis-GMA/TEGDMA和双甲基丙烯酸酯体系。我们将设计和生产新的 对酶或水解降解不敏感的单体及其聚合物， 愈合技术，以显着延长这些复合材料的疲劳寿命，并制定智能抗菌 仅在需要时在口腔环境中激活的组分。我们提出三个具体目标 针对这三个关键发展。在具体目标1中，我们建议通过更换 包含在现有聚合物和粘合剂中的可水解酯基与水解稳定的醚 基团在相应的聚合物和粘合剂。在具体目标2中，我们将开发自我修复 牙科复合材料（SHDC）将自动修复难以检测的微裂纹， 临床上无法修复。自主自愈将显著提高这些材料的耐久性 通过防止由口腔中遇到的热和机械挑战引起的灾难性故障， 环境在具体目标3中，我们建议通过以下方式为系统建立自卫能力： 用新型偶联剂官能化的纳米颗粒， 暴露于细菌攻击或水解降解。这些新系统的完整性和耐用性将是 与基于Bis-GMA/TEGDMA的商业系统相比， 口腔环境，包括致龋生物膜、酶降解、热循环疲劳和 机械循环疲劳我们期望，新的材料，具有这三个实现的功能， 具体目标，将大大超过目前的Bis-GMA-TEGDMA为基础的商业性能 材料在这些挑战下。因此，可以预测，新系统将提供一个显著的 延长使用寿命，至少是两倍。新系统中的所有功能都可以轻松集成 U 01-RFA获奖者开发的其他修复系统，可用于复合材料 和牙科粘合剂。我们计划分享我们的数据和资源，并与获奖者合作， 所有可行的程序，以实现本计划的目标的方式。