Biomechanical Characterization and Modeling of Human TMJ Disc

人类颞下颌关节盘的生物力学表征和建模

• 批准号: 8596464
• 负责人: Gregory John Wright
• 金额: $ 4.3万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8596464
• 关键词: Affect; Anatomy; Biomechanics; Cells; Charge; Clinical; Coupling; Data; Development; Diagnosis; Diagnostic; Early Diagnosis; Electric Conductivity; Elements; Environment; Event; Extracellular Matrix; Family suidae; Fibrocartilages; Functional disorder; Goals; Human; Human Development; Hydration status; Intervertebral disc structure; Ions; Jaw; Joints; Knee; Knowledge; Lead; Liquid substance; Lubrication; Magnetic Resonance Imaging; Malocclusion; Mandible; Mastication; Measures; Mechanics; Meniscus structure of joint; Metabolic; Metabolism; Methods; Modeling; Molecular; National Institute of Dental and Craniofacial Research; Nickel; Nutrient; Outcome; Outcome Study; Pathologic; Pathology; Pathway interactions; Patients; Permeability; Property; Protocols documentation; Relaxation; Replacement Therapy; Reporting; Research; Simulate; Solid; Stress; Structure of articular disc of temporomandibular joint; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Tissues; Translating; United States National Institutes of Health; arthropathies; base; density; human data; in vivo; innovation; intervertebral disk degeneration; mathematical model; novel; public health relevance; regenerative therapy; research study; soft tissue; solute; success; three-dimensional modeling; tool

DESCRIPTION (provided by applicant): Temporomandibular joint (TMJ) disorder affects over 10 million people in the US each year. Despite ongoing research, there is a current lack of understanding in the TMJ biomechanics field related to human biomechanical function. This has been attributed to the low success rate of replacement therapy as well as the inability to manage progressive pathology of the joint. As a result, significant advances in research are essential to understand the pathophysiology of joint degeneration for early diagnosis and management. It is generally believed that pathological mechanical loadings, e.g. sustained jaw clenching or malocclusion, trigger a cascade of molecular events leading to TMJ disc degeneration, which has been implicated in over 30% of TMJ disorders. Our previous studies indicate that the nutrient concentrations dictate TMJ cell metabolism and matrix synthesis. Due to the technical difficulty of measuring the in vivo mechanical and nutrient environment inside the TMJ, a finite element model must be developed to simulate the effect of mechanical loading on the nutrient diffusivities inside the TMJ disc. A deeper understanding of the biomechanics, i.e. mechanical environment and effect on the nutrient environment, could lead to developments in TMJ disorder diagnosis and management. Therefore, the objective of this research study is to develop an accurate mathematical model (finite element model) based on the first ever human characterization of the human mechanical and transport properties. Our central hypothesis is that sustained mechanical loading can alter solute transport and nutrient levels in the TMJ disc as well as mechanical function resulting in disc derangement and degeneration. We further hypothesize that by testing human TMJ discs with porcine TMJ discs under the same protocol, we will better understand the relevance of the porcine model to the human. Aim 1: Determine mechanical properties of human and porcine TMJ discs and correlate the mechanical properties to the tissue composition. Aim 2: Determine strain-dependant transport properties of human and porcine TMJ discs. Aim 3: Develop 3D patient specific multiphasic mechano-electrochemical finite element model of the human TMJ disc. The outcome of this study will yield 1) a patient specific finite element model to build a pathway between biomechanics and pathobiology 2) the first study to characterize the biomechanical properties of the human TMJ disc 3) the first study to establish the porcine biomechanical model in reference to the human for developments in tissue replacements and regenerative therapies. Finally, the project will bring the clinical field crucial, non-invasive method to screen and manage progression of patients with TMJ disorders.

描述（由申请人提供）：颞下颌关节（TMJ）疾病每年影响美国超过1000万人。尽管正在进行的研究，有一个目前缺乏了解，在颞下颌关节生物力学领域有关人类的生物力学功能。这是由于替代治疗的成功率低以及无法管理关节的进行性病理。因此，研究的重大进展对于了解关节退行性变的病理生理学以进行早期诊断和管理至关重要。通常认为，病理性机械负荷，例如持续的咬紧牙关或咬合不正，触发了导致TMJ椎间盘退变的分子事件级联，其与超过30%的TMJ病症有关。我们以前的研究表明，营养浓度决定TMJ细胞代谢和基质合成。由于测量TMJ内的体内机械和营养环境的技术难度，必须开发有限元模型来模拟机械载荷对TMJ盘内营养扩散率的影响。更深入地了解生物力学，即力学环境和营养环境的影响，可能会导致TMJ疾病的诊断和管理的发展。因此，本研究的目的是开发一个准确的数学模型（有限元模型）的基础上，有史以来第一次人类表征的人体力学和运输性能。我们的中心假设是，持续的机械负荷可以改变溶质运输和营养水平的颞下颌关节盘以及机械功能，导致光盘紊乱和退化。我们进一步假设，通过在相同的方案下用猪TMJ盘测试人类TMJ盘，我们将更好地理解猪模型与人类的相关性。目的1：测定人和猪颞下颌关节盘的机械性能，并将机械性能与组织成分相关联。目的2：确定人和猪颞下颌关节盘的应变依赖性传输特性。目的3：建立颞下颌关节盘三维多相力学-电化学有限元模型。本研究的结果将产生：1）患者特定有限元模型，以建立生物力学和病理学之间的通路; 2）第一项研究，以表征人类TMJ椎间盘的生物力学特性; 3）第一项研究，以建立与人类相关的猪生物力学模型，用于组织置换和再生治疗的开发。最后，该项目将带来临床领域的关键，非侵入性的方法来筛选和管理TMJ疾病患者的进展。