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Immuno-pathophysiology of Lymphocytic Foci in Sjogren?s Syndrome

干燥综合征淋巴细胞病灶的免疫病理生理学

基本信息

批准号：
8518291
负责人：
Cuong Q Nguyen
金额：
$ 22.65万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8518291
关键词：
Affect Animal Model Autoantigens Autoimmune Diseases Autoimmune Process B-Lymphocytes Biological Biopsy Bladder Cells Cephalic Chronic Clinical Connective Tissue Diseases Data Dementia Development Disease Disease Progression Disease susceptibility Exhibits Exocrine Glands Fatigue Foundations Frequencies Functional disorder Future Gene Rearrangement Genetic Gland Goals Gonadal Steroid Hormones Grant Human Hypergammaglobulinemia Impaired cognition Individual Interleukin-17 Kidney Labial Salivary Gland Lacrimal gland structure Lead Lung Lymphocyte Manuscripts Memory Loss Mental disorders Natural Killer Cells Neuropathy Organ Patients Peripheral Phase Population Preparation Publications Rheumatoid Factor Role Salivary Glands Sensory Serum Sjogren&apos s Syndrome Skin Solid Symptoms Syndrome T-Cell Receptor T-Lymphocyte Testing Therapeutic Time Vagina Woman Xerostomia abstracting base cell type cytokine design gene therapy genetic profiling interleukin-22 men mouse model new technology novel prevent response sexual dimorphism single cell analysis vector

项目摘要

Sjogren's syndrome (SjS) is an autoimmune disease characterized primarily by exocrine gland dysfunction, specifically, the salivary and lacrimal glands. It can be systemic by affecting other organs including the Gl tract, skin, lungs, vasculature, kidneys, bladder and vagina. Involvement of the musculature can lead to flbromyalgla-llke symptoms and chronic fatigue. Approximately 20% of patients develop various neuropathies, including sensory, peripheral, cranial and myelopathic neuropathies exhibited by cognitive impairments such as dementia, lack of concentration, memory loss and various psychiatric disorders. As with many autoimmune connective tissue diseases, there exists a sexual dimorphism in SjS with women affected 10- to 20-times more frequently than men, suggesting a role for sex hormones in disease susceptibility or progression. A unique feature of SjS in both humans and animal models Is the formation of lymphocytic focus (LF) in the salivary and lacrimal glands. Although one of the more predominant cell populations infiltrating the glands is the pathogenic THI 7 cells that produce IL-17 and IL-22 cytokines, little is known about frequencies of infiltrating cells secreting these cytokines and the genetic profiles of their individual T cell receptors. Using a novel technology called microengraving designed for single cell analysis, this study aims to provide a proof of concept in examining individual TH17 cells that produce IL-22. To achieve this goal, two specific aims will be carried out: 1) characterizing individual IL-22-secretlng cells infiltrating the labial salivary glands (LSG) of SjS patients, and 2) identifying the T cell receptor (TCR)-P gene rearrangement of Individual IL-22 secreting cells in LSG of SjS patients. Results of the proposed study, therefore, will establish proof of concept for identification and characterization of individual T cells with their corresponding TCR-0 gene rearrangement and secreted products.

干燥综合征（SjS）是一种以外分泌腺功能障碍为主要特征的自身免疫性疾病。