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Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases

Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖转移酶抑制剂作为治疗传染病的多功能药物
批准号:
nhmrc : GNT1147368
负责人:
A/Pr Lieve Naesens
金额:
$75.56万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
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英文摘要
Due to the increase in resistance to many of the frontline drugs to treat bacterial and parasitic infections, there is an urgent need to develop new pipelines for drug discovery against the pathogens that are causative agents of this diseases. This project pioneers the blocking of nucleotide synthesis to develop new drug leads to treat malaria, human tuberculosis, African sleeping sickness, Chagas disease and uropathogenic E.coli infections.
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Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
  • 批准号:
    nhmrc : 1147368
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.09万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Lieve Naesens
  • 依托单位:
An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
  • 批准号:
    nhmrc : 1030353
  • 项目类别:
    Project Grants
  • 资助金额:
    $33.38万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Lieve Naesens
  • 依托单位:
Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
  • 批准号:
    nhmrc : 569703
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $28.6万
  • 财政年份:
    2009
  • 负责人:
    A/Pr Lieve Naesens
  • 依托单位:
海外基金