Role of Extracellular Calcium in Obesity, Hypertension, and Diabetes

非裔美国人(AA)经历了不成比例的肥胖率、高血压和糖尿病。特别的 令人感兴趣的是，高血压AA也有肥胖或糖尿病的倾向。响应于频繁的集群 对于再生障碍性贫血中的肥胖、高血压和糖尿病，研究人员提出，这些疾病有一个共同的 病理生理途径。最近的证据表明，这种共同的联系可能与饮食中的钙有关。虽然这件事 该项目专注于一种共同的病理生理途径来解释高血压合并糖尿病的患病率。 在非裔美国人中，还有心理社会、行为和环境因素 影响疾病发病率和发病率。与我们的社区参与和外联核心WE合作 将直接调查钙在农村糖尿病、高血压和肥胖症管理中的作用 北卡罗来纳州的一些地区。外联核心将调查非生物因素，如社会互动 (家庭)、饮食和锻炼；因此，该项目有望加强对以下方面的系统层面的了解 在存在健康差异的社区环境中，钙与这些疾病的关系。因此， 本项目的首要目标是更充分地阐明钙的作用。

African Americans (AA) experience disproportionate rates of obesity, hypertension, and diabetes. Of particular interest is the tendency for hypertensive AA to also be obese or diabetic. In response to the frequent clustering of obesity, hypertension, and diabetes in AA, researchers have proposed that these diseases share a common pathophysiologic pathway. Recent evidence suggests that this common link could be dietary calcium. While this project focuses on a common pathophysiologic pathway to explain the prevalence of hypertension with diabetes and obesity in African Americans, there are also psychosocial, behavioral, and environmental factors that influence disease incidence and morbidity. Working with our Community Engagement and Outreach Core we will directly investigate the role of calcium in the management of diabetes, hypertension, and obesity in rural areas of North Carolina. The Outreach Core will investigate non-biological factors such as social interaction (family), diet, and exercise; consequently, this project is expected to enhance a systems-level understanding of the relationship of calcium to these diseases in a community setting with identified health disparities. Therefore, the overarching goal of this proiect is to more fully elucidate the role of Ca^