Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention R

描述（由申请人提供）：第十一届癌症预防研究前沿国际年会将于2012年10月16日至19日在加州阿纳海姆的希尔顿阿纳海姆酒店举行。AACR长期以来一直是癌症预防研究的支持者，旨在通过改变生活方式和早期发现和治疗来预防癌症。这个年度AACR会议于2002年首次亮相，仍然是世界上最杰出的癌症预防研究会议。医生，科学家，患者和幸存者倡导者从该领域领先的基础，临床，流行病学和行为科学家那里了解最新的翻译发现。该会议促进跨学科合作，加速预防研究领域的进展，并提高对癌症预防在降低癌症发病率和死亡率方面至关重要性的认识。今年会议的主题是“综合癌症预防”。该计划将侧重于确定有助于癌症的启动和演变的因素，以及我们对这些因素的理解如何用于识别风险人群，确定预防方法，并在一般人群中评估这些方法。该会议不仅将关注癌症预防研究领域的发展方向及其演变，还将有助于塑造和定义癌症预防研究的演变。以统一的方式将基础，临床和人口方法结合起来，以最广泛的方式研究癌症预防研究，将有助于促进来自不同学科的科学家的交叉施肥。科学进步正在改变癌症预防领域，为我们提供了了解人类致癌作用的分子基础所需的信息和技术，并以前所未有的准确性和有效性识别和干预疾病过程。通过将我们对基础科学的理解转化为临床应用，在公共卫生层面上看到了好处。致癌起始和进展中的几个步骤是癌症预防的目标。一级预防是避免暴露于致癌物或致癌过程，可针对未显示癌前病变迹象的广大人群。运动和避免吸烟是这种干预的例子。最成功的一级预防策略之一是开发疫苗，如HBV和HPV疫苗。二级预防工作受到了很多关注，包括筛查和早期发现，这通常是针对更具体的风险人群。这类预防的例子包括巴氏试验（用于宫颈癌）、乳房X光检查（用于乳腺癌）、结肠镜检查（用于结直肠癌）和新兴的检测乳腺癌和肺癌的新成像技术。研究发现，癌前病变可能比以前认识到的更常见，了解哪些癌前病变进展为癌症，而另一些则没有进展，这将是至关重要的。最后，三级预防旨在预防复发或第二次癌症。 公共卫生相关性：本次会议旨在提高公众、学术界、政府和行业对癌症预防研究在降低癌症发病率和死亡率方面至关重要性的认识。它还促进基础，临床，流行病学和行为科学的协调，重点研究，有望加速癌症预防。最近的科学进展为我们提供了阐明人类致癌作用的分子基础所需的信息和技术;了解为什么一些癌前病变进展为癌症，而另一些则不会，这对个性化治疗和避免过度治疗至关重要。通过教学讲座，海报展示，教育会议和非正式网络活动的组合，本次会议为科学家，医生和其他卫生专业人员提供了一个场所，以了解和讨论该领域最前沿的研究，并形成跨学科的合作，这将加速癌症预防研究的进展。

DESCRIPTION (provided by applicant): The Eleventh Annual International Conference on Frontiers in Cancer Prevention Research will take place October 16-19, 2012, at the Hilton Anaheim Hotel in Anaheim, California. The AACR has long been a supporter of cancer prevention research aimed at preventing cancer through lifestyle changes and early detection and treatment. This annual AACR conference debuted in 2002 and remains the pre-eminent cancer prevention research conference in the world. Physicians, scientists, patients, and survivor advocates learn about the latest translational discoveries from the leading basic, clinical, epidemiologic, and behavioral scientists in the field. The conference fosters interdisciplinary collaborations, accelerates progression in the field of prevention research, and promotes awareness of the vital importance of cancer prevention in reducing cancer incidence and mortality. The theme for this year's conference is "Integrative Cancer Prevention". The program will focus on identifying the factors that contribute to the initiation and evolution of cancer and how our understanding of these factors can be used to identify those at risk, identify approaches for prevention, and assess such approaches in the general population. The conference will not only focus on where the field of cancer prevention research is headed and how it is evolving, but will also help to shape and define the evolution of cancer prevention research. Bringing together basic, clinical, and population approaches in a unified way to study cancer prevention research in the broadest terms will help to promote cross-fertilization of scientists from diverse disciplines. Scientific advances are transforming the field of cancer prevention by providing us with the information and technology needed to understand the molecular underpinnings of carcinogenesis in humans and to identify and intervene in disease processes with unprecedented accuracy and effectiveness. By translating our understanding of the basic science into clinical application, benefits are being seen at the public health level. Several steps within carcinogenic initiation and progression are targets for cancer prevention. Primary prevention is the avoidance of exposure to carcinogens or the carcinogenic process and may be directed at the broad population of individuals who show no sign of pre-malignancy. Exercise and avoidance of tobacco are examples of this type of intervention. And one of the most successful primary prevention strategies is the development of vaccines such as those for HBV and HPV. Secondary prevention efforts are receiving a lot of attention and include screening and early detection, which are generally directed toward a more specified risk population. Examples of this type of prevention include pap test (for cervical cancer), mammography (for breast cancer), colonoscopy (for colorectal cancer) and emerging new imaging techniques to detect breast and lung cancer. Studies have found that premalignant lesions may be more common than previously realized and it will be crucial to understand who some premalignant lesions progress to cancer and others do not. Finally, tertiary prevention is aimed at preventing recurrence or second cancers. PUBLIC HEALTH RELEVANCE: This conference promotes public, academic, government, and industry awareness of the vital importance of cancer prevention research in reducing cancer incidence and mortality. It also catalyzes coordinated, focused research in basic, clinical, epidemiologic and behavioral science that promises to accelerate cancer prevention. Recent scientific advances are providing us with the information and technology needed to elucidate the molecular underpinnings of carcinogenesis in humans; understanding why some premalignant lesions progress to cancer while others do not will be crucial to personalizing therapy and avoiding overtreatment of patients. Through a combination of didactic lectures, poster presentations, educational sessions, and informal networking events, this conference provides a venue for scientists, physicians, and other health professionals to learn about and discuss the most cutting-edge research in the field and form interdisciplinary collaborations that will accelerate progression in cancer prevention research.