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Identification and Characterization of Cell Autonomous Determinants that Promote

Identification and Characterization of Cell Autonomous Determinants that Promote
促进细胞自主决定因素的鉴定和表征
批准号：
8555536
负责人：
PIER PAOLO PANDOLFI
金额：
$24.56万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-26 至 2012-08-02
来源：
https://reporter.nih.gov/project-details/8555536
关键词：
AdenocarcinomaAnimalsBehaviorBiologicalBiological FactorsCancer BiologyCancer PatientCellsCessation of lifeCollaborationsDevelopmentDisciplineEpithelial CellsGene MutationGenesGeneticGenetic DeterminismGenetic ScreeningHumanIn VitroInsertional MutagenesisIntestinal ObstructionLaboratoriesMalignant neoplasm of prostateMediatingMetastatic Neoplasm to the BoneModelingMorbidity - disease rateMouse StrainsMutant Strains MiceMutationNeoplasm MetastasisOrganPopulationPreclinical Drug EvaluationProcessPropertyProstaticProstatic NeoplasmsRegulationResearchRoleSignal PathwaySleeping BeautySpecimenStem cellsSystemTestingTimeUnited Statesbasebonecell typehuman diseaseimprovedin vivokillingsmenmetastatic processmortalitymouse modelneoplastic cellnoveltherapeutic targettumortumor initiation

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中文摘要
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英文摘要
The Pandolfi laboratory proposes to investigate cell autonomous genetic and cell biological factors that influence the metastatic potential of prostate cancer (CaP) cells. Specifically, we will determine whether certain genetic mutations associated with CaP development confer metastatic capacity onto otherwise non-metastatic cells or increase a tumor cell subpopulation with intrinsic propensity to metastasis. Furthermore, we will perform an in vivo screen to probe for genes that, when deregulated, promote prostate cancer metastasis. We will use the gained information to refine and improve existing CaP mouse models utilized in basic cancer biology and preclinical drug evaluation efforts.
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