Identification and Characterization of Cell Autonomous Determinants that Promote

促进细胞自主决定因素的鉴定和表征

• 批准号: 8555536
• 负责人: PIER PAOLO PANDOLFI
• 金额: $ 24.56万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2012-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555536
• 关键词: Adenocarcinoma; Animals; Behavior; Biological; Biological Factors; Cancer Biology; Cancer Patient; Cells; Cessation of life; Collaborations; Development; Discipline; Epithelial Cells; Gene Mutation; Genes; Genetic; Genetic Determinism; Genetic Screening; Human; In Vitro; Insertional Mutagenesis; Intestinal Obstruction; Laboratories; Malignant neoplasm of prostate; Mediating; Metastatic Neoplasm to the Bone; Modeling; Morbidity - disease rate; Mouse Strains; Mutant Strains Mice; Mutation; Neoplasm Metastasis; Organ; Population; Preclinical Drug Evaluation; Process; Property; Prostatic; Prostatic Neoplasms; Regulation; Research; Role; Signal Pathway; Sleeping Beauty; Specimen; Stem cells; System; Testing; Time; United States; base; bone; cell type; human disease; improved; in vivo; killings; men; metastatic process; mortality; mouse model; neoplastic cell; novel; therapeutic target; tumor; tumor initiation

The Pandolfi laboratory proposes to investigate cell autonomous genetic and cell biological factors that influence the metastatic potential of prostate cancer (CaP) cells. Specifically, we will determine whether certain genetic mutations associated with CaP development confer metastatic capacity onto otherwise non-metastatic cells or increase a tumor cell subpopulation with intrinsic propensity to metastasis. Furthermore, we will perform an in vivo screen to probe for genes that, when deregulated, promote prostate cancer metastasis. We will use the gained information to refine and improve existing CaP mouse models utilized in basic cancer biology and preclinical drug evaluation efforts.

Pandolfi实验室提议研究细胞自主遗传和细胞生物学 影响前列腺癌（CaP）细胞转移潜力的因素。具体来说，我们将确定 与 CaP 发育相关的某些基因突变是否赋予其他疾病转移能力 非转移细胞或增加具有内在转移倾向的肿瘤细胞亚群。 此外，我们将进行体内筛选，以探查那些在解除管制时促进前列腺的基因。 癌症转移。我们将利用获得的信息来完善和改进现有的 Cap 小鼠模型 用于基础癌症生物学和临床前药物评价工作。