Innate immune cell protection and colon cancer

先天免疫细胞保护与结肠癌

• 批准号: nhmrc : 1047903
• 负责人: Dr Lisa Mielke
• 金额: $ 40.63万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/innate-immune-cell-colon-cancer/111979
• 关键词: Innate; immune; cell; protection; colon

Colorectal cancer is a leading cause of cancer-related deaths worldwide. Chronic inflammation is recognized as a predisposing factor for the development of colon cancer, but the molecular mechanisms linking inflammation and tumourigenesis have remained elusive. Our work will dissect the cellular and molecular circuitry that leads to tumourigenesis and investigate interventions aimed to significantly slow or prevent tumour formation. This work will have significant implications for treatments of intestinal inflammation and colon cancer.

结直肠癌是全球癌症相关死亡的主要原因。慢性炎症被认为是结肠癌发生的易感因素，但炎症与肿瘤发生之间的分子机制仍不明确。我们的工作将剖析导致肿瘤发生的细胞和分子电路，并研究旨在显著减缓或防止肿瘤形成的干预措施。这项工作将对肠道炎症和结肠癌的治疗具有重要意义。