Innate immune sensing of Proteotoxic Stress

蛋白毒性应激的先天免疫感应

• 批准号: nhmrc : 2003756
• 金额: $ 50.14万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/innate-immune-sensing-proteotoxic-stress/1780209
• 关键词: Innate; immune; sensing; Proteotoxic; Stress

Cells recycle old components using a system called the proteasome. Some people are born without parts of the proteasome, and they suffer from a disease associated with inflammation. We have identified the molecular trigger for this inflammation. Our findings are also relevant for patients being treated with proteasome inhibitors. In some of these diseases, such as lupus, inflammation can be a side-effect of proteasome inhibitor therapy, and we can now reduce this and make the treatments safer.

细胞利用一种叫做蛋白酶体的系统回收旧的成分。有些人天生就没有蛋白酶体的一部分，他们患有与炎症有关的疾病。我们已经确定了这种炎症的分子触发器。我们的研究结果也与正在接受蛋白酶体抑制剂治疗的患者相关。在其中一些疾病中，如狼疮，炎症可能是蛋白酶体抑制剂治疗的副作用，我们现在可以减少这种副作用，使治疗更安全。