NAVBO Developmental Vascular Biology Workshop

项目概要/摘要： 血管生物学领域在过去的二十年里经历了信息爆炸。在鉴定可溶性血管生成因子、不溶性细胞外基质调节剂和调节血液和淋巴生长过程的受体信号通路方面已经取得了显著进展。这一进展的大部分动力来自于这样一种假设，即靶向血管生成可以阻止肿瘤的生长，并对许多其他疾病产生益处。鉴于信息如此丰富，讨论和跨学科思想交流的必要性日益增加。 第三届NAVBO发育血管生物学研讨会将汇集科学家，共同关注了解发育中血管形成的过程以及这些信息如何与病理状态相关。该计划的开发包括在关键/经典主题的最新未发表的信息，但也整合了新的新兴主题。我们的目标是促进高水平的思想交流，这可能会导致新的综合见解，并最终突出新的治疗方法，以改善广泛的病理状态，包括但不限于癌症，关节炎，视网膜病变和血栓性疾病，导致心肌梗死和中风。 在此申请中，我们要求资金部分支持这一跨学科的国际会议，该会议将汇集来自学术和私营部门的研究人员，博士后研究员和来自不同研究领域的研究生，进行为期四天的激烈讨论和研究。会议将于2008年1月30日至2月2日在加利福尼亚州蒙特雷太平洋格罗夫的阿西洛马会议场地举行。

Project Summary/Abstract: The field of vascular biology has experienced an explosion of information during the two decades. Noticeable advances have been made in the identification of soluble angiogenic factors, insoluble extracellular matrix modulators and receptor signaling pathways that regulate the process of blood and lymphatic growth. Much of this progress was fueled from the hypothesis that targeting angiogenesis could halt the growth of tumors and result in a benefit to many other diseases. In light of this wealth of information there is an increased need for discussion and interdisciplinary exchange of ideas. The third NAVBO Developmental Vascular Biology Workshop will bring together scientists with the common interest of understanding the process of blood vessel formation in development and how this information pertains to pathological states. The program was developed to include the latest unpublished information in the key/classical topics, but has also integrated novel emerging themes. It is our aim to foster a high-level exchange of ideas that might lead to new integrative insights and ultimately highlight new therapeutic approaches for amelioration of a broad spectrum of pathological states including, but not restricted to cancer, arthritis, retinopathies and thrombotic disorders leading to myocardial infarction and stroke. In this application we request funds to partially support this interdisciplinary, international conference which will serve to bring together investigators from the academic and private sectors, post-doctoral fellows, and graduate students from diverse fields of study for four days of intense discussion and study. The conference will be held at the Asilomar Conference Grounds, Pacific Grove, Monterey, CA from January 30th to February 2nd, 2008.