Evaluation of the Role of PSA Inhibitors in the Prevention and/or Therapy of

PSA 抑制剂在预防和/或治疗中的作用评估

• 批准号: 8719550
• 负责人: JOHN ISAACS
• 金额: $ 16.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719550
• 关键词: Ablation; American; Androgen Receptor; Androgens; Biological Markers; Cells; Cessation of life; Development; Disease; Disseminated Malignant Neoplasm; Epithelial Cells; Evaluation; Local Therapy; Malignant neoplasm of prostate; Names; Normal tissue morphology; Paper; Peptide Hydrolases; Prevention; Principal Investigator; Prostate; Prostate-Specific Antigen; Recurrence; Relapse; Role; Screening for Prostate Cancer; Serine Protease; Systemic Therapy; Writing; chemotherapeutic agent; chymotrypsin; docetaxel; hormone refractory prostate cancer; human male; inhibitor/antagonist; men; novel; palliative; programs; prostate cancer cell; response; standard of care; therapeutic target

Prostate cancer cells, like normal prostate secretory-luminal epithelial cells, produce very high levels of the PSA. PSA is aptly named, in that it is produced at high levels exclusively by prostate cells and is not produced in significant amounts by any other normal tissue in the human male. PSA is a chymotrypsin-like serjne protease that is used extensively as a biomarker to screen for prostate cancer, to detect recurrence following local therapies and to follow response to systemic therapies for metastatic disease. PSA, however, is also a well credentialed therapeutic target for prostate cancer. The focus on PSA's role as a biomarker has made perhaps made

前列腺癌细胞，就像正常的前列腺分泌腔上皮细胞一样，产生非常高水平的 PSA。PSA的名字很贴切，因为它只由前列腺细胞高水平产生，而不是 由人类男性的任何其他正常组织大量产生。PSA是一种类凝乳杆菌胰蛋白酶 丝氨酸蛋白酶被广泛用作前列腺癌筛查和复发检测的生物标志物 在局部治疗之后，并跟踪对转移性疾病的系统治疗的反应。然而，PSA， 也是前列腺癌的有效治疗靶点。关注PSA作为生物标志物的作用 做了或许做了