Participation in the Eastern Cooperative Oncology Group

描述(由申请人提供)：CINJ自1994年以来一直是经社理事会成员机构，继续成为经社理事会研究的一个活跃和重要的地点。CINJ疾病特异性多模式诊所非常适合开发、实施和参与经社理事会的科学、试验和管理。CINJ的主要成员和附属机构对ECOG赞助或认可的临床试验的应计收入继续增长。INJ教职员工积极参与经社理事会的多个委员会，12名教职员工参加了13个委员会，其中2人担任主席，2人担任副主席。CINJ是第一阶段U10的持有者，并实施一个强大的第一阶段方案，作为小组研究的潜在资源，几项经社理事会研究首先在CINJ试行。CINJ教职员工也越来越多地参与群体科学，有13项研究由6名CINJ教员开发、启动或主持，其中包括3项胸科研究、7项GU研究、2项GL研究和1项化学预防研究。其他的也在开发中。CINJ的研究人员在将重组疫苗试验引入前列腺癌方面发挥了重要作用，进一步的此类试验正在开发中。CINJ实验室调查人员还与相关科学项目一起参与了经社理事会的研究。例如，相关科学项目检测了bcl2对耐药的调控，乳腺癌耐药蛋白SCLC的多态性正在分析中。另一个项目与硒化学预防试验相联系，评估手术标本中各种IHC和FISH标记物的影响。CINJ是一个ECOG预防中心，我们的几名教职员工参加了预防委员会的活动。尽管绿茶研究未能启动，但CINJ的另一项研究建议在石蜡切片中测试一种独特的抗体，以区分Barrett的癌前病变作为化学预防的候选来源。CINJ还成为ECOG症状管理联盟的成员：一名医生、一名药剂师和几名护士正在该联盟中积极工作，以启动试验我们建议使用这笔赠款：1)继续我们强大的ECOG委员会的参与；2)设计和参与ECOG多模式研究；3)将我们的同行评议机构实验室作为小组科学的潜在来源；4)促进CINJ和我们广泛的附属机构网络的持续收益；5)监测患者进入、方案遵守情况和数据质量；6)及时提交数据表格；7)继续与ECOG感兴趣的其他ECOG成员一起开发试验性研究；以及8)加强我们的基础科学实验室与集团临床试验计划的互动。

DESCRIPTION (provided by applicant): CINJ, an ECOG member institution since 1994, continues to grow as an active and important site for ECOG studies. The CINJ disease specific multi-modality clinics are ideally suited for development, implementation, and participation in ECOG science, trials, and administration. CINJ main member and affiliate accrual to ECOG sponsored or endorsed clinical trials continues to grow. CINJ faculty actively participate in multiple ECOG committees, and 12 faculty participate in 13 committees, 2 as chair and 2 as vice-chairs. CINJ is a phase I U10 holder, and operates a strong phase I program, which serves as a potential resource for group studies, and several ECOG studies were first piloted at CINJ. CINJ faculty also have a growing participation in group science and 13 studies were developed, activated, or chaired by 6 CINJ faculty and include 3 thoracic studies, 7 GU studies, 2 Gl studies, and 1 chemoprevention study. Others are also in development. CINJ investigators were instrumental in bringing recombinant vaccine trials to prostate cancer, and further such trials are in development. CINJ lab investigators also participate in ECOG studies with the correlative sciences projects. For example correlative science projects tested bcl-2 modulation of resistance, and breast cancer resistance protein polymorphisms SCLC are under analysis. Another project is linked to the selenium chemoprevention trial and evaluates the impact of various IHC and FISH markers in surgical specimens. CINJ is an ECOG Prevention Center, and several of our faculty participate in the Prevention Committee activities. Despite the failure of the green tea study to launch, another study from CINJ proposes to test a unique antibody in paraffin sections to distinguish Barrett's pre-malignant esophageal lesions as a candidate source for chemoprevention. CINJ also became a member of the ECOG Symptom Management Consortium: one physician, one pharmacist and several nurses are actively working in this consortium to activate trials We propose to use this grant to: 1) continue our strong ECOG committee participations; 2) design and participate in ECOG multi-modality studies; 3) engage our peer-reviewed institutional laboratories as potential sources for group science; 4) foster continued accrual from CINJ and from our broad network of affiliated institutions; 5) monitor patient entry, protocol compliance, and data quality; 6) submit timely data forms; 7) continue to develop pilot studies with other ECOG members of interest to ECOG; and 8) enhance the interaction of our basic science laboratories and the group's clinical trials programs.