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Inhibitors and Probes of HIV-1 Cell Fusion

Inhibitors and Probes of HIV-1 Cell Fusion
HIV-1 细胞融合的抑制剂和探针
批准号：
8741404
负责人：
Carole Bewley
金额：
$79.44万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741404
关键词：
AntigensBinding SitesBiochemicalBiological FactorsCarbohydratesCell fusionDevelopmentGlycoproteinsGoalsHIV Envelope Protein gp120HIV-1ImmobilizationLocal MicrobicidesMediatingNMR SpectroscopyNational Institute of Diabetes and Digestive and Kidney DiseasesNatural Products ChemistryPeptidesProteinsResolutionTechniquesVaccinesbasecarbohydrate binding proteindesigninhibitor/antagonistinterestnovelreceptorreceptor bindingsmall molecule

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英文摘要
The Natural Products Chemistry Section, LBC, NIDDK has several ongoing projects whose long term aim is to identify and design inhibitors and probes of HIV-1 Envelope-mediated cell fusion. These include the design and development of new gp41-derived peptides and proteins that have dual functions as inhibitors and immunogens, discovery and high resolution structural characterization of new carbohydrate binding proteins that potently inhibit HIV-1 Entry through carbohydrate-mediated interactions with gp120/gp41, discovery of natural product inhibitors of HIV-1 fusion, and structural and mechanistic studies of HIV-1 Envelope - coreceptor interactions.
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Discovery of Natural Products and Natural Product-Like Inhibitors
NMR Facility Management and Application of NMR Spectroscopy
Inhibitors and Probes of HIV-1 Cell Fusion
Discovery of Natural Products and Natural Product-Like Inhibitors
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