Intracellular Actions of the Lymphangiogenic Growth Factor VEGF-D in Fibroblasts

成纤维细胞中淋巴管生成因子 VEGF-D 的细胞内作用

• 批准号: 8545893
• 负责人: Souheil El-Chemaly
• 金额: $ 16.2万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8545893
• 关键词: Area; Biological Process; Cultured Cells; DNA Polymerase II; Elements; Fibroblasts; Genetic Transcription; Growth Factor; Homeostasis; Human; Indium; Lung; Lung diseases; Nuclear; Play; Process; RNA; Role; Testing; Therapeutic Effect; Transcriptional Regulation; Vascular Endothelial Growth Factor D; clinical application; density; in vivo; paired basic amino acid cleaving enzyme; trafficking; transcription factor

Density-dependent nuclear accumulation of VEGF-D similar to that in cultured cells was observed with fibroblasts in fibrotic areas of human lung suggests that nuclear VEGF-D plays an important role in fibroblast homeostasis In vivo, particularly perhaps in fibrotic lung disease. As VEGF-D processing is known to result from actions of furin and protein conve^rtase (PC)-5, manipulation of VEGF-D processing might produce desirable therapeutic effects on its nuclear trafficking and biological function with potential clinical application.

在人肺纤维化区域的成纤维细胞中观察到类似于培养细胞中的VEGF-D的密度依赖性核积累，表明核VEGF-D在体内成纤维细胞稳态中起重要作用，特别是可能在纤维化肺病中。由于已知VEGF-D加工是弗林蛋白酶和蛋白质转化酶（PC）-5作用的结果，因此操纵VEGF-D加工可能对其核运输和生物学功能产生期望的治疗效果，具有潜在的临床应用。

项目成果

Lymphatics in lymphangioleiomyomatosis and idiopathic pulmonary fibrosis.

• DOI: 10.1183/09059180.00009311
• 发表时间: 2012-09-01
• 期刊: European respiratory review : an official journal of the European Respiratory Society
• 作者: Glasgow CG;El-Chemaly S;Moss J
• 通讯作者: Moss J