IGF::OT::IGF SBIR PHASE I TOPIC 331: BIOPSY GUIDANCE WITH COHERENT RAMAN SPECTROSCOPY

该合同将开发一种用于相干拉曼散射（CRS）光谱的小型化光纤探针，该探针可安装在标准活检针中，并允许对具有高密度恶性细胞的组织进行实时指导，该组织将被活检进行分子分析，同时保留未涉及的组织。CRS是一种非破坏性、高灵敏度的体内分子分析激光光谱技术。准确性，安全性和活体活检指导将在脑癌（胶质瘤）大鼠模型中得到证明，并可在未来扩展到其他癌症。预计这种方法可以减少使用新兴分子谱分析技术获得诊断样本所需的重复活检次数，从而降低患者的成本和风险。

This contract will develop a miniaturized fiber-optic probe for coherent Raman scattering (CRS) spectroscopy that fits inside a standard biopsy needle and allows real-time guidance toward tissue with a high density of malignant cells, which would be biopsied for molecular analysis while sparing uninvolved tissue. CRS is a non-destructive and highly sensitive laser spectroscopy technique for in vivo molecular profiling. Accuracy, safety and in vivo biopsy guidance will be demonstrated in a brain cancer (glioma) rat model and can be extended to other cancers in the future. It is anticipated that this approach can reduce the number of repeat biopsies required to obtain samples for diagnosis with emerging molecular profiling techniques and thus reduce cost and risk to patients.