LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

LRRK2 和其他新型外泌体蛋白在帕金森病中的作用

基本信息

  • 批准号:
    8554393
  • 负责人:
  • 金额:
    $ 29.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-30 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): It is generally recognized that there are inadequate measures of detecting disease progression and biochemical pathways associated with Parkinson's disease (PD) in clinical populations, and that this lack of effective biomarkers has hindered, and is expected to continue to impede, successful clinical trials for efficacious neuroprotective (disease-retarding or halting) therapeutics. Genetic and pathological studies have identified several proteins linked to late-onset PD, and these proteins have provided insight into pathways that might be central to disease. However, these proteins have been difficult to analyze in PD cases due to the limited availability of disease-susceptible tissue, and studies are usually confined to post-mortem derived specimens. We have made the recent observation that LRRK2, and other proteins linked genetically and pathologically to PD, are detectable in exosomes isolated from human urine samples. Using a multiplex mass spectrometry approach, we can quantify 935 proteins from clinical urine exosome samples, and 140 of these proteins are linked to neurodegeneration by pathway analysis. This proposal seeks to 1) determine whether there are biomarkers associated with PD susceptibility and/or progression in urinary exosome-proteomes derived from PD patients versus controls, and 2) to determine if LRRK2 expression and/or phosphorylation are significantly lowered in the urinary exosomes of individuals treated with the potent LRRK2 kinase inhibitor sunitinib (a multi-kinase inhibitor compound), to establish an assay for on-target effects for future LRRK2 inhibitor clinica trials. Potential biomarkers of interest will be validated in replication cohorts, and the most promising leads will be further explored in future multi-center studies.
描述(由申请人提供):人们普遍认为,在临床人群中,检测与帕金森病(PD)相关的疾病进展和生化途径的措施不足,并且缺乏有效的生物标志物已经阻碍并预计将继续阻碍有效的神经保护(疾病延缓或停止)治疗方法的成功临床试验。遗传和病理研究已经确定了几种与迟发性帕金森病相关的蛋白质,这些蛋白质为了解可能是疾病核心的途径提供了见解。然而,由于疾病易感组织的可用性有限,这些蛋白质很难在PD病例中分析

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Andrew B West其他文献

Andrew B West的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Andrew B West', 18)}}的其他基金

Project 3: LRRK2 mediated macrophage responses in PD
项目 3:LRRK2 介导的 PD 巨噬细胞反应
  • 批准号:
    10469390
  • 财政年份:
    2018
  • 资助金额:
    $ 29.01万
  • 项目类别:
Project 3: LRRK2 mediated macrophage responses in PD
项目 3:LRRK2 介导的 PD 巨噬细胞反应
  • 批准号:
    9976625
  • 财政年份:
    2018
  • 资助金额:
    $ 29.01万
  • 项目类别:
Mechanisms of LRRK2 Mediated Neurotoxicity
LRRK2 介导的神经毒性机制
  • 批准号:
    9883049
  • 财政年份:
    2018
  • 资助金额:
    $ 29.01万
  • 项目类别:
Mechanisms of LRRK2 Mediated Neurotoxicity
LRRK2 介导的神经毒性机制
  • 批准号:
    10117999
  • 财政年份:
    2018
  • 资助金额:
    $ 29.01万
  • 项目类别:
Exosome LRRK2 in Predicting Parkinson Disease Phenotypes
外泌体 LRRK2 预测帕金森病表型
  • 批准号:
    9135110
  • 财政年份:
    2016
  • 资助金额:
    $ 29.01万
  • 项目类别:
Exosome LRRK2 in Predicting Parkinson Disease Phenotypes
外泌体 LRRK2 预测帕金森病表型
  • 批准号:
    9282760
  • 财政年份:
    2016
  • 资助金额:
    $ 29.01万
  • 项目类别:
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
LRRK2 和其他新型外泌体蛋白在帕金森病中的作用
  • 批准号:
    9035559
  • 财政年份:
    2015
  • 资助金额:
    $ 29.01万
  • 项目类别:
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
LRRK2 和其他新型外泌体蛋白在帕金森病中的作用
  • 批准号:
    8472329
  • 财政年份:
    2012
  • 资助金额:
    $ 29.01万
  • 项目类别:
Mechanisms of LRRK2 Mediated Neurotoxicity
LRRK2 介导的神经毒性机制
  • 批准号:
    8071508
  • 财政年份:
    2010
  • 资助金额:
    $ 29.01万
  • 项目类别:
Mechanisms of LRRK2 Mediated Neurotoxicity
LRRK2 介导的神经毒性机制
  • 批准号:
    7886438
  • 财政年份:
    2010
  • 资助金额:
    $ 29.01万
  • 项目类别:

相似海外基金

Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
  • 财政年份:
    2023
  • 资助金额:
    $ 29.01万
  • 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
  • 批准号:
    2601817
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
    Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
  • 批准号:
    2029039
  • 财政年份:
    2020
  • 资助金额:
    $ 29.01万
  • 项目类别:
    Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
  • 批准号:
    9888417
  • 财政年份:
    2019
  • 资助金额:
    $ 29.01万
  • 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
  • 批准号:
    17K11318
  • 财政年份:
    2017
  • 资助金额:
    $ 29.01万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9320090
  • 财政年份:
    2017
  • 资助金额:
    $ 29.01万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
  • 财政年份:
    2017
  • 资助金额:
    $ 29.01万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9761593
  • 财政年份:
    2017
  • 资助金额:
    $ 29.01万
  • 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
  • 批准号:
    BB/M50306X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 29.01万
  • 项目类别:
    Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
  • 批准号:
    288272
  • 财政年份:
    2013
  • 资助金额:
    $ 29.01万
  • 项目类别:
    Miscellaneous Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了