Cancer Center Support Grant

描述(由申请人提供)：对癌症的基因理解导致了增强的个体风险评估，改进了筛查指南，并在癌症预防、早期发现以及在某些情况下进行靶向治疗的基础上改善了结果。亨斯迈癌症研究所(HCI)在这个个性化的肿瘤学领域做出了非凡的贡献。HCI拥有独特的研究资源来支持遗传和人口研究，犹他州人口数据库(UPDB)，令人信服的肿瘤学基因发现历史，以及加快该平台翻译进展的战略计划。我们已经与备受全国赞誉的犹他州医疗网络InterMountain Healthcare建立了联盟，将我们州超过80%-85%的癌症患者的数据连接到UPDB，使犹他州的整个人口能够组成一个癌症研究实验室，进行遗传、人口和结果研究。犹他州有七个美洲原住民部落或民族，以及广泛的农村和边境人口，他们的癌症预后很差。我们的目标是作为国家研究资源，解决这些服务不足的人群的需求，以改善癌症预防和护理。 HCI研究分为五个项目，提供癌症焦点、跨学科交流和合作的环境：细胞生长和分化的核控制；细胞反应和调节；成像、诊断和治疗；胃肠癌；以及癌症控制和人口科学。这些计划整合了133名成员的活动，他们拥有4500万美元的外部赠款支持，以及超过1700万美元的NCI直接费用。目前获奖期间的癌症重点研究记录在1374份独特的出版物中，其中26%是与一个或多个癌症中心成员合作的。十三个癌症中心共享资源为我们的科学家提供支持，提供对专业仪器、分析、服务、研究材料以及专家咨询和协作的访问。 我们申请资金来支持我们的癌症中心支持补助金(CCSG)的21-25年。2006年8月任命了新的执行主任玛丽·贝克勒博士。在她的领导下，HCI制定了一项指导未来五年的计划，包括扩大HCI的癌症专科医院，扩大HCI的临床前研究的遗传平台，开发研究治疗中心(包括第一阶段计划)，以及扩大人口科学(包括流行病学和行为研究)，以影响癌症幸存者的护理并减少健康差距。

DESCRIPTION (provided by applicant): The genetic understanding of cancer has led to enhanced individual risk assessment, improved screening guidelines, and improved outcomes based on cancer prevention, early detection, and, in some cases, targeted therapy. Huntsman Cancer Institute (HCI) is positioned to make exceptional contributions in this individualized oncology arena. HCI has a unique research resource to support genetic and population studies, the Utah Population Database (UPDB), a compelling history of genetic discovery in oncology, and a strategic plan to accelerate translational advances from this platform. We have forged an alliance with Intermountain Healthcare, a nationally acclaimed Utah health network, linking data for more than 80-85 percent of the cancer patients in our State to the UPDB, enabling the entire population of Utah to comprise a cancer research laboratory for genetic, population, and outcomes research. Utah is home to seven Native American tribes or nations as well as extensive rural and frontier populations that have poor cancer outcomes. We aim to serve as a national research resource for addressing the needs of these underserved populations to improve cancer prevention and care. HCI research is organized into five Programs that provide an environment of cancer focus, transdisciplinary exchange, and collaboration: Nuclear Control of Cell Growth and Differentiation; Cell Response and Regulation; Imaging, Diagnostics, and Therapeutics; Gastrointestinal Cancers; and Cancer Control and Population Sciences. These Programs integrate the activities of 133 members who have $45 million in extramural grant support, with more than $17 million in NCI direct costs. Cancer-focused research during the current award period is documented in 1,374 unique publications, of which 26 percent are collaborative with one or more Cancer Center members. Thirteen Cancer Center Shared Resources support our scientists, providing access to specialized instrumentation, assays, services, research materials, and expert consultation and collaboration. We request funds to support Years 21-25 of our Cancer Center Support Grant (CCSG). A new Executive Director, Mary Beckerle, Ph.D., was appointed in August 2006. Under her leadership, HCI has developed a plan to guide the next five years, including expansion of HCI's cancer specialty hospital, expansion of HCI's genetic platform for pre-clinical studies, development of a Center for Investigational Therapeutics (including a Phase I program), and expansion of population science (including epidemiological and behavioral research) to impact care of cancer survivors and reduce health disparities.