PHAHs and Thyroid Cancer Risk in DoDSR Cohort
DoDSR 队列中的 PHAH 和甲状腺癌风险
基本信息
- 批准号:8663258
- 负责人:
- 金额:$ 66.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-08-01 至 2017-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAnimalsAreaAromatic HydrocarbonsCYP1A1 geneCYP1A2 geneCYP1B1 geneCYP2D6 geneCYP2E1 geneCYP3A4 geneCYP3A5 geneChemicalsClassificationCodeDataDepartment of DefenseDiagnosisDiagnosticDioxinsDrug Metabolic DetoxicationEnvironmental ExposureEnzymesEtiologyExposure toFamilyFishesFunctional disorderGSTM1 geneGSTP1 geneGSTT1 geneGenderGeneral PopulationGenesGenetic PolymorphismGlucuronosyltransferaseGlutathione S-TransferaseHealthcareHeightHomeostasisHumanIncidenceIodide PeroxidaseJointsKnowledgeLeadLinkMalignant neoplasm of thyroidMetabolismMilitary PersonnelNested Case-Control StudyOccupationalPapillary thyroid carcinomaPhasePolicy MakerPolychlorinated BiphenylsPopulationProductionPublic HealthRaceRecording of previous eventsRegulationReportingResearchRiskSamplingSerumServicesSolidSourceSpecimenTestingThyroid GlandThyroid HormonesUGT1A1 geneUGT1A8 UDP-glucuronosyltransferaseUnited StatesWeightadministrative databasebasebilirubin uridine-diphosphoglucuronosyl transferase 1A10cancer riskcase-basedchemical groupcohortexposed human populationmanmonoamine-sulfating phenol sulfotransferasenovelorganochlorine pesticidephenyl etherpublic health prioritiesrepositoryresidencesexsulfotransferasetumor registrytumorigenesis
项目摘要
DESCRIPTION (provided by applicant): During the past several decades, an increased incidence of papillary thyroid cancer has been reported in many parts of the world, including the United States, with unknown reasons. Emerging evidence indicates that polybrominated diphenyl ethers (PBDEs) and other polyhalogenated aromatic hydrocarbons (PHAHs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides, are able to alter thyroid hormone homeostasis and cause thyroid dysfunction. These changes are suspected to lead to tumorigenesis of the thyroid gland. While animal studies have provided solid evidence in support of the link between PHAHs and thyroid cancer risk, no human studies have been conducted to test this novel hypothesis that exposure to PBDEs and other PHAHs increases the risk of papillary thyroid cancer. Here, we propose a case-control study nested in a large US military cohort to examine 1) the association between PBDE/PHAH exposure and papillary thyroid cancer risk; 2) the association between PBDE/PHAH exposure and thyroid hormone disruption; and 3) whether the risk of papillary thyroid cancer and thyroid hormone disruption associated with environmental exposure to PHAHs varies by genetic polymorphisms in major genes coding for enzymes involved in the regulation, metabolism, or functional activities of PHAHs and endogenous thyroid hormones. The proposed study will be conducted using PRE-DIAGNOSTIC sera from the Department of Defense Serum Repository (DoDSR), which contains over 44 million serum specimens collected from over 9 million people since 1989. Cases will be ascertained via a centralized military tumor registry. The study will include 800 incident cases of papillary thyroid cancer that were diagnosed between 2000 and 2012 with pre-diagnostic sera banked in the DoDSR. One control will be matched to each case based on age, gender, and the date of serum draw. Data on potential confounders, including age, weight and height, sex, and race, will be available for each subject through linkage with military healthcare and administrative databases. Results from the study will not only advance our knowledge of the poorly understood etiology of papillary thyroid cancer, but also provide important scientific evidence to policy makers who regulate the production and use of these compounds and will intrigue other research areas to figure out ways to eliminate the existing sources of PBDEs and other PHAHs.
描述(申请人提供):在过去的几十年里,乳头状甲状腺癌的发病率在世界上许多地区都有增加的报道,包括美国,原因不明。新的证据表明,多溴联苯醚(PBDEs)和其他多卤代芳香烃(PHAHs),包括多氯联苯(PCbs)和有机氯农药,能够改变甲状腺激素的动态平衡,导致甲状腺功能障碍。这些变化被怀疑是导致甲状腺肿瘤发生的原因。虽然动物研究已经提供了确凿的证据支持PHAHs和甲状腺癌风险之间的联系,但还没有进行人体研究来检验这一新的假设,即暴露于多溴二苯醚和其他PHAHs会增加乳头状甲状腺癌的风险。在这里,我们提出了一项嵌套在美国军队大型队列中的病例对照研究,以检查1)PBDE/PHAH暴露与乳头状甲状腺癌风险之间的关系;2)PBDE/PHAH暴露与甲状腺激素干扰之间的关联;以及3)与环境暴露PHAHs相关的乳头状甲状腺癌和甲状腺激素干扰的风险是否因编码参与PHAHs和内源性甲状腺激素的调节、代谢或功能活动的酶的主要基因的遗传多态而不同。这项拟议的研究将使用国防部血清库(DoDSR)的诊断前血清进行,该库包含自1989年以来从900多万人那里收集的4400万份血清样本。病例将通过一个集中的军事肿瘤登记来确定。这项研究将包括2000至2012年间被诊断为乳头状甲状腺癌的800例病例,诊断前血清储存在DoDSR中。每个病例将根据年龄、性别和血清采集日期匹配一个对照。关于潜在混杂因素的数据,包括年龄、体重和身高、性别和种族,将通过与军队医疗保健和行政数据库的链接,为每个受试者提供。这项研究的结果不仅将增进我们对乳头状甲状腺癌病因知之甚少的知识,还将为监管这些化合物的生产和使用的政策制定者提供重要的科学证据,并将启发其他研究领域找到消除现有多溴二苯醚和其他PHAHs来源的方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jennifer Ann Rusiecki其他文献
Jennifer Ann Rusiecki的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jennifer Ann Rusiecki', 18)}}的其他基金
PHAHs and Thyroid Cancer Risk in DoDSR Cohort
DoDSR 队列中的 PHAH 和甲状腺癌风险
- 批准号:
8514605 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
PHAHs and Thyroid Cancer Risk in DoDSR Cohort
DoDSR 队列中的 PHAH 和甲状腺癌风险
- 批准号:
9059082 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
Health Effects of the Deepwater Horizon Disaster:the Coast Guard Responder Cohort
深水地平线灾难对健康的影响:海岸警卫队响应者队列
- 批准号:
8449733 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
Health Effects of the Deepwater Horizon Disaster:the Coast Guard Responder Cohort
深水地平线灾难对健康的影响:海岸警卫队响应者队列
- 批准号:
8582551 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
PHAHs and Thyroid Cancer Risk in DoDSR Cohort
DoDSR 队列中的 PHAH 和甲状腺癌风险
- 批准号:
8370634 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
Health Effects of the Deepwater Horizon Disaster:the Coast Guard Responder Cohort
深水地平线灾难对健康的影响:海岸警卫队响应者队列
- 批准号:
8222313 - 财政年份:2012
- 资助金额:
$ 66.33万 - 项目类别:
Pesticide Exposure and DNA Methylation in Pesticide Applicators
农药施用器中的农药接触和 DNA 甲基化
- 批准号:
7532468 - 财政年份:2008
- 资助金额:
$ 66.33万 - 项目类别:
Pesticide Exposure and DNA Methylation in Pesticide Applicators
农药施用器中的农药接触和 DNA 甲基化
- 批准号:
7935479 - 财政年份:2008
- 资助金额:
$ 66.33万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 66.33万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 66.33万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 66.33万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 66.33万 - 项目类别:
Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
- 批准号:
2889694 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 66.33万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)