ALEXSA Standardization for Clinical Use

描述（由申请人提供）：本STTR第二阶段申请旨在完成针对教育者、儿科、预防和流行病学用途的独一无二的物质使用和反社会行为（c）（ALEXSA（c））责任和暴露评估。ALEXSA系统首先由NIDA K奖资助，它使用一种有趣的计算机格式获取儿童报告（8至13岁）数据，文盲青年可以完成。九个风险领域（因子得分）和超过40个风险因子分量表可以用来测量易患性和早期形式的问题物质使用（SU）和慢性行为问题。ALEXSA可由儿童护理专业人员对儿童群体或个人进行管理。它在儿童报告评估中具有独特的发展适当性，测量特征的广度，定制评估的灵活性，用户友好性以及研究和干预的实用性。ALEXSA为客户提供了一种年轻人认为比纸质表格更保密的格式，自动数据存储，并在完成后立即得分（例如，进行筛查和转介干预）。ALEXSA的心理测量特性之一是一个简短的屏幕，一年后在12岁以下的高危青年中，SU的预测准确率为85%。因此，这种筛查早在药物使用障碍发病之前就能发现高风险青年，为预防提供了长期机会。第一阶段的工作开发了一个高度便携的上网本版本和一个PDA屏幕版本的ALEXSA。第二阶段的工作将使用复杂的方法和广泛的评估来完善ALEXSA，以便对个人进行深入的临床评估（类似于智商测试）。ALEXSA评分将标准化为美国普通人群。ALEXSA系统产品将根据专家评审的具体专业需求量身定制。将创建用户手册。所有的产品都将被改进为高质量的。总的来说， ALEXSA创新的研究工具将成为一种提供最先进评估的工具，这将有助于专业人员满足超过93，000名行为健康专业人员，超过150，000名初级保健医生和41，000名学校心理学家每年600万次早期干预服务和SU/SUD风险筛查的要求。ALEXSA的创新功能，广泛和基于证据的分量表和分数，以及心理测量特性将使其能够填补几个大型利基市场的空白，并为潜在竞争对手创造障碍。

DESCRIPTION (provided by applicant): This STTR Phase II application is to finalize the one-of-its-kind Assessment of Liability and Exposure to Substance use and antisocial behavior(c) (ALEXSA(c)) for educator, pediatric, prevention and epidemiology uses. The ALEXSA system, first funded by a NIDA K-Award, acquires child-report (8- to 13-year-olds) data using an illustrated, computer format that is enjoyable and can be completed by illiterate youth. Nine risk domains (factor scores) and over 40 risk factor subscales canbeusedtomeasure liability to, and early forms of, problematic substance use (SU) and chronic behavior problems. The ALEXSA can be administered by child care professionals to groups of children or individuals. It is unique among child-report assessments in developmental appropriateness, breadth of characteristics measured, flexibility for tailored assessment, user-friendliness, and utility for research and intervention. The ALEXSA offers customers a format perceived by youth to have greater confidentiality than paper forms, automated data storage, and scores immediately upon completion (e.g., for screening and referral to intervention). Among ALEXSA's psychometric properties is a brief screen with an overall 85% predictive accuracy of SU one-year later among high-risk youth younger than 12 years old. This screen thus detects youth at high risk for substance use disorder long before its onset providing long-term opportunity for prevention. Phase I work developed a highly portable net book version and a PDA screen version of the ALEXSA. Phase II efforts will refine the ALEXSA using sophisticated methods and an extensive evaluation to enable in-depth clinical assessment of individuals (akin to IQ tests). ALEXSA scoring will be standardized to the U.S. general population. ALEXSA system products will be tailored to the needs of specific professions based on expert reviews. User's Manuals will be created. All products will be refined to be publish-quality. Collectively, this augmentation of the innovative ALEXSA research instrument into a tool that provides state-of-the-art assessment will assist professionalism meeting mandates for 6 million annual early intervention services and SU/SUD risk screenings by over 93,000 behavioral health professionals, over 150,000 primary care physicians and 41,000 school psychologists. The ALEXSA's innovative features, broad and evidence-based subscales and scores, and psychometric properties will permit it to fill gaps in several large niche markets and create barriers to potential competitors.